Senior Computational Biologist ctDNA Genomics

Memorial Sloan Kettering Cancer Center; New York (NY); Hybrid; USD 114,000 - 182,000; Full time

Job summary

Memorial Sloan Kettering Cancer Center (MSK) in New York City is seeking a Senior Computational Biologist to develop and apply computational methods for liquid biopsy, clonal hematopoiesis, and translational cancer genomics. You will support analyses using MSK-ACCESS, CMO-CH, and related sequencing platforms, collaborating with clinical, laboratory, and computational teams.

You will lead analyses of ctDNA and clinical outcomes, build scalable workflows, and contribute to manuscripts and grants,

Qualifications

• Master's degree or PhD in Computational Biology, Bioinformatics, Statistics, Computer Science, or related field
• Strong programming skills in Python and/or R
• Experience analyzing NGS or large-scale genomic datasets
• Experience with workflow management systems (Nextflow, Snakemake, CWL, or WDL)
• Experience in Linux/HPC/cloud environments
• Proficiency with Git/GitHub and container tech (Docker or Apptainer/Singularity)
• Strong statistical analysis and scientific communication skills

Responsibilities

• Analyze and interpret NGS data from MSK-ACCESS/CMO-CH and related assays
• Lead computational analyses of ctDNA and clinical outcomes data
• Develop, automate, and maintain scalable genomic analysis workflows
• Build statistical and predictive models integrating genomic and clinical data
• Collaborate with multidisciplinary teams across computational, laboratory, and clinical research
• Contribute to manuscripts, grants, and translational research initiatives

Skills

Python

R

Statistical analysis

Scientific communication

Collaboration

Education

Master's degree

PhD (preferred)

Tools

Nextflow

Snakemake

CWL

WDL

Git/GitHub

Docker

Apptainer/Singularity

Job description

Memorial Sloan Kettering Cancer Center (MSK) in New York City is seeking a Senior Computational Biologist to develop and apply computational methods for liquid biopsy, clonal hematopoiesis, and translational cancer genomics. You will support analyses using MSK-ACCESS, CMO-CH, and related sequencing platforms, collaborating with clinical, laboratory, and computational teams.

You will lead analyses of ctDNA and clinical outcomes, build scalable workflows, and contribute to manuscripts and grants,