Senior Clinical Trial Manager (Sr. CTM)

BioSpace; Brisbane (CA); On-site; USD 182,000 - 194,000; Full time

Job summary

Nurix Therapeutics is seeking a Senior Clinical Trial Manager to oversee regional or multi-trial programs, shaping study design and vendor contracts. You will guide budget forecasting, mentor CTMs, and drive audit readiness across trials in a dynamic, fast-paced environment.

The role requires 8–10+ years in clinical operations, regulatory knowledge, and strong leadership. Travel ~25% and onsite work in Brisbane, CA are expected.

Qualifications

• B.S./B.A. in biological sciences; 8–10+ years in the industry.
• Willing to travel 25% for programs.
• Extensive knowledge of FDA/EMA/ICH/GCP regulations.
• Experience managing global trials or multi-region programs.
• Proven vendor/CRO relationship management at a strategic level.
• Mentoring CTMs/CTAs.
• Strong executive presence and ability to influence without direct authority.
• Excellent organization to manage a portfolio of trials.

Responsibilities

• Own operational strategy across multiple trials and/or regions.
• Shape protocol strategy and study design inputs.
• Lead vendor/CRO selection and contract negotiations.
• Escalation point for vendor or site issues.
• Forecast budgets and flag financial risks across the portfolio.
• Mentor and develop CTMs/CTAs.
• Lead audit readiness and manage inspections.
• Represent Clinical Operations at program level and externally at events.
• Anticipate risk and drive preventive process improvements.
• Lead cross-functional strategic initiatives.

Skills

Regulatory knowledge (FDA/EMA/ICH/GCP)

Global/multi-region trials

Mentoring CTMs/CTAs

Executive presence

Strategic vendor management

Education

B.S./B.A. in biological sciences

Job description

Senior Clinical Trial Manager (Sr CTM)

You’ve run trials well — now run more of them, and help others do the same. You’ll manage a portfolio of trials or a full region, own vendor strategy end-to-end, and become the person other CTMs turn to when something’s stuck.

Position Description

This individual manages clinical regions and/or multiple trials simultaneously, with broad involvement in work central to Nurix’s strategic goals, and plays a key role in developing junior clinical operations staff.

The Opportunity

• Own operational strategy across multiple clinical trials and/or a full geographic region
• Shape protocol strategy and provide senior input on study design and data collection approach
• Lead vendor/CRO selection strategy and own contract negotiation leverage across trials
• Serve as the escalation point for vendor or site issues CTMs can’t resolve on their own
• Own program-level budget forecasting and proactively flag financial risk across the portfolio
• Mentor and develop CTMs and CTAs, providing hands‑on guidance and informal supervision
• Lead audit readiness strategy and serve as the point person across multiple trials during inspections
• Represent Clinical Operations at the program or franchise level, and represent Nurix externally at professional events
• Anticipate risk across the trial portfolio and shape process or strategy to prevent issues before they surface
• Lead cross-functional strategic initiatives rather than simply participating in them

What You’ll Bring

• S./B.A. in biological sciences with 8-10+ years of relevant industry experience
• Ability to travel as required for the program (25%)
• Deep working knowledge of FDA, EMA, ICH, and GCP regulations and guidelines
• Proven experience managing global trials or multi-region programs
• Track record leading vendor/CRO relationships at a strategic, not just operational, level
• Experience mentoring or developing junior CTMs/CTAs
• Strong executive presence and ability to influence without direct authority
• Comfortable operating with minimal oversight and setting direction for others
• Outstanding organizational skills, able to manage a portfolio of trials simultaneously
• Thrives in a fast-paced, small-company environment, adjusting priorities as needed

Salary Range: $181,900 – $193.827 annually

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location: Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands‑on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.