Senior Clinical Trial Lead – Global Oncology Trials

Summit Therapeutics, Inc.; Miami (FL); On-site; USD 158,000 - 185,000; Full time

Job summary

Summit Therapeutics Inc. in the United States seeks a Senior Clinical Trial Manager (Sr.

CTM) to provide strategic leadership and operational oversight of global oncology trials, from protocol support to study closeout and inspection readiness. You will mentor CTMs and CRAs, oversee site selection, enrollment, monitoring and data quality, manage CRO relationships, ensure regulatory compliance, and drive continuous improvement across clinical operations while traveling up to 20% to sites and

Qualifications

• 8–10+ years of clinical operations experience in sponsor pharma/biotech.
• 7+ years of direct CTM experience overseeing phase II/III international oncology trials.
• Ability to travel internationally up to 20%.

Responsibilities

• Oversee site selection, feasibility, activation, enrollment, monitoring, issue escalation, and closeout.
• Lead CRO oversight and ensure high-quality study execution and data monitoring strategies.
• Draft and approve study plans, ICFs, CRFs, and related documents.
• Lead risk-based quality management and mitigate signals and actions.
• Manage TMF quality reviews and inspection readiness.
• Represent Clinical Operations in cross-functional study teams.

Skills

Clinical operations

Leadership

Regulatory knowledge

Education

Bachelor’s degree in life sciences

Tools

CTMS experience

Job description

Summit Therapeutics Inc. in the United States seeks a Senior Clinical Trial Manager (Sr.

CTM) to provide strategic leadership and operational oversight of global oncology trials, from protocol support to study closeout and inspection readiness. You will mentor CTMs and CRAs, oversee site selection, enrollment, monitoring and data quality, manage CRO relationships, ensure regulatory compliance, and drive continuous improvement across clinical operations while traveling up to 20% to sites and