Senior Clinical Manager - Immunogenetics and Transplant Diagnostics (ITD)

1200 The General Hospital Corporation; Boston (MA); On-site; USD 100,000 - 126,000; Full time

Job summary

Mass General Brigham's Immunogenetics and Transplant Diagnostics (ITD) unit seeks a senior clinical manager to lead daily lab operations across sites in Boston. You will oversee staffing, quality, safety and regulatory compliance for high-complexity histocompatibility testing, coordinating with pathology leadership and research teams.

You will drive process improvements, manage budgets, and collaborate with transplant physicians, IT, and compliance colleagues to support urgent clinical decisions

Qualifications

• CLIA qualifications for general supervisor for high complexity laboratory
• Experience leading large histocompatibility laboratories supporting multi-hospital transplant programs and organ procurement organizations (OPO)
• Expertise across regulatory compliance and quality management in clinical labs

Responsibilities

• Oversee daily lab operations, staffing, workflow, quality and safety
• Ensure compliance with federal, state, and accreditation requirements
• Coordinate clinical trials and data management with investigators and QA teams
• Lead staffing, training, competency assessment and continuing education

Skills

Operational leadership

Communication

Collaboration

Quality management

Staffing management

Process improvement

Project management

Laboratory systems

Education

Bachelor's Degree in Laboratory Sciences

Tools

Laboratory information systems

Job description

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Immunogenetics and Transplant Diagnostics (ITD) service currently operates across two laboratory sites, one at each academic medical center. Together, the BWH Tissue Typing and MGH Histocompatibility laboratories provide comprehensive support for solid organ (kidney, heart, lung, liver, pancreas), as well as hematopoietic progenitor cell transplantation and specialized non-transplant diagnostic testing. ITD performs ~60,000 HLA/histocompatibility-related tests per year. Collectively, the ITD laboratories support the combined Mass General Brigham transplant programs which performed more than 750 organ transplants in 2025 alone. In addition, the MGB ITD Service serves is the Organ Procurement Organization histocompatibility laboratory for OPTN Region 1 and supports nine additional organ and HPCT transplant hospitals across New England. The senior clinical manager will partner with ITD and MGB Pathology leadership to build a fully integrated immunogenetics laboratory.

Summary Responsible for the daily operation of the lab: staffing, workflow, quality, safety, and regulatory compliance. The position provides daily management and strategic direction for the laboratories. Ensures compliance with all relevant federal, state, and accreditation requirements. This role oversees operations at multiple sites and requires strong management skills, as well as a collaborative approach when working with leaders both locally and within the system. This is an on-site role, rotating sites as operational and situational needs require. Does this position require Patient Care? No

Essential Functions

• Develops and maintains QA systems to ensure a high level of performance and effective remedial actions to address deviations from performance specifications.
• Review performance information, identify opportunities for improvement, and take action to eliminate root causes of performance that do not meet expectations.
• Review event management reports, investigate complaints or problems, and analyze data to identify trends or patterns.
• Ensure a validation protocol and validation summary is created for new or changed processes.
• Assigns, monitors, and supervises work to ensure compliance with laboratory SOPs and applicable federal, state, and accreditation requirements, including health/safety and patient confidentiality.
• Ensures the laboratory is prepared for all regulatory reviews and inspections (e.g., TJC, CAP, FACT).
• Oversees the coordination of clinical trials with principal investigators, study coordinators, quality assurance, and compliance.
• Manages computer systems to access clinical laboratory results, produce worksheets on components processed, and perform other data collection or analysis activities.
• Conducts interviews and recommends candidates for hiring in accordance with departmental policies to ensure adequate staffing for the laboratory.
• Responsible for staff orientation, training, competency assessment, and continuing education, including required department training (safety, infection control, compliance).

Qualifications Required Experience

The successful applicant must meet CLIA qualifications for general supervisor for high complexity laboratory performing histocompatibility testing (CFR § 493.1461), ASHI standard E.5.1, as well as OPTN and the Massachusetts Department of Health regulations.

The ideal candidate will also demonstrate experience and success with the following:

• Progressive operational leadership experience managing large, complex histocompatibility laboratories supporting multi-hospital transplant programs and organ procurement organizations (OPO).
• Knowledge of OPTN Region 1 operations is critical.
• Proven success overseeing all aspect of high-volume, 24/7 laboratory operations including staffing, workflow optimization, quality management, turnaround time, regulatory compliance, competency assessment, delivery of key performance indicators (e.g. turnaround times), capital/equipment planning, and budgeting/financial stewardship.
• Experience partnering with Pathology and laboratory medical and clinical leadership to support multiple transplant programs and coordinate testing and reporting urgent, time-sensitive transplant and other clinical decisions.
• Exceptional communication and execution skills with demonstrated ability to communicate clearly across technical, clinical and executive stakeholders, establish accountability and ensure consistent follow-through on operational, quality and strategic priorities.
• Exceptional collaboration and relationship-building skills with a track record of working effectively with external partners including transplant physicians, surgeons, clinical care teams, OPO leaders, IT, billing and compliance, quality and administrative leaders to advance laboratory operational excellence.
• Demonstrated success leading process improvement, technology implementation, assay implementation/validation, and operational change within a complex clinical laboratory environment.
• Broad technical expertise across the full scope of Histocompatibility testing, including:
  • Next-generation sequencing (NGS)–based HLA typing
  • HLA antibody identification and characterization
  • Donor‑specific antibody (DSA) testing
  • Physical (flow and CDC) and virtual crossmatching
  • Chimerism testing
  • ABO testing
• Strong experience in workforce leadership including development of sustainable staffing models, mentoring, career development, performance management, scheduling, productivity, inventory management and resource allocation.
• Experience developing and maintaining comprehensive quality management systems, including proficiency testing, competency programs, corrective and preventative actions, document control and continuous improvement initiatives.
• Expertise with laboratory information systems and the integration of laboratory testing platforms/instrumentation, interfaces, and information technology solutions to support complex clinical workflows.

Education

Bachelor's Degree Laboratory Sciences required or Master's Degree Related Field of Study preferred Can this role accept experience in lieu of a degree? No

Licenses and Credentials

ASCP Certified Medical Technologist [MLT, MT, MLA, Histologists] - Generic - HR Only required Experience Lab experience 5-7 years required and Demonstrated leadership experience in hospital-based CLIA laboratory 3-5 years required

Knowledge, Skills and Abilities

• Detailed knowledge of all regulatory requirements, including CAP, Joint Commission, and CLIA.
• Expert knowledge of laboratory health and safety protocols.
• Strong innovative attributes to remain on top of technology shifts.
• Effective written and verbal communication skills.
• Read, write and comprehend English sufficiently to communicate with patients, laboratory and others.
• Strong knowledge of personnel and employment practices.
• Ability to effectively manage staffing levels and workloads.
• Ability to effectively interview and train new employees.

Additional Job Details (if applicable)

Remote Type Onsite Work Location 275 Charles Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $99,632.00 - $126,027.20/Annual Grade 8 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package.

EEO Statement

1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People‑Focused, half Performance‑Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

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