Senior Cardiovascular NAMs Scientist – In Vitro Models

BioSpace; Indianapolis (IN); On-site; USD 126,000 - 205,000; Full time

Job summary

Lilly is seeking a scientist to anchor cardiovascular NAMs capabilities in NAMs/CIVMs within Investigative Toxicology. This role focuses on hiPSC-derived models, 2D and 3D systems, and organoid platforms to uncover drug-induced cardiac and vascular liabilities.

You will collaborate across teams to advance translational safety science and contribute to regulatory-aligned efforts. The successful candidate will lead mechanistic investigations, qualify readouts, and work with external partners to

Qualifications

• PhD with training in cardiac biology or cardiovascular electrophysiology.
• Experience in advanced cardiovascular in vitro models desired.
• Ability to design and execute independent experiments.

Responsibilities

• Develop and apply human-relevant in vitro models for cardiovascular liabilities.
• Design mechanistic investigations of proarrhythmia, cardiomyopathy and DIVI.
• Implement electrophysiological and contractile readouts for safety assessment.
• Use 3D cardiovascular platforms for mechanistic studies and chronic dosing.
• Collaborate with cross-functional teams and CROs on NAMs work.
• Engage in pre-competitive consortia and publish findings.

Skills

Cardiovascular biology

In vitro modelling

Electrophysiology

3D CIVM platforms

Data analysis

Education

PhD in Pharmacology or related field

Tools

MEA recordings

hiPSC-CMs

vessel-on-a-chip

Job description

Lilly is seeking a scientist to anchor cardiovascular NAMs capabilities in NAMs/CIVMs within Investigative Toxicology. This role focuses on hiPSC-derived models, 2D and 3D systems, and organoid platforms to uncover drug-induced cardiac and vascular liabilities.

You will collaborate across teams to advance translational safety science and contribute to regulatory-aligned efforts. The successful candidate will lead mechanistic investigations, qualify readouts, and work with external partners to