Senior Biologics Discovery Scientist

Salubris Biotherapeutics Inc; Gaithersburg (MD); On-site; USD 70,000 - 100,000; Full time

Job summary

Salubris Biotherapeutics, Inc. is seeking a Senior Research Associate to support discovery and preclinical characterization of novel biologics for CVM diseases. You will independently execute cell-based and molecular assays in disease-relevant models and contribute data driving candidate selection.

Collaborative team environment in a fast-paced biotech setting. The role emphasizes mammalian cell culture, qPCR, Western blot, and in vitro assays to profile potency, engagement, and stability of

Qualifications

• BS with 3+ years, or MS with 1+ years, of relevant laboratory experience in biology, biochemistry, pharmacology, physiology, or a related discipline.
• Strong hands-on mammalian cell culture skills, including primary cells; experience with hepatocytes, adipocytes, macrophages, and/or cardiomyocytes is highly desirable.
• Demonstrated experience independently running and troubleshooting cell-based assays with functional readouts (reporter, signaling, gene expression, or cell function).
• Experience in core molecular and biochemical methods: RNA extraction, RT-qPCR, Western blot, and immunoassays (ELISA or MSD).
• Sound troubleshooting and data analysis skills.
• Excellent organization, documentation, and communication skills; able to manage multiple projects and priorities in a dynamic environment.
• A positive, can-do attitude; thrives in a fast-paced, evolving environment; stays proactive and solution-oriented when facing ambiguity or setbacks.

Responsibilities

• Design, execute, and troubleshoot plate-based functional assays to characterize biologic candidates, including receptor-signaling and reporter assays (e.g., pERK, luciferase/reporter readouts), target-gene expression (qPCR), and cell-function readouts.
• Culture and maintain disease-relevant primary and immortalized cells, such as primary hepatocytes, hepatic stellate cells, adipocytes, macrophages, fibroblasts, and various rodent or human cell lines.
• Run CVM-specific in vitro models and assays.
• Support in vitro biochemical and biophysical characterization of complex biologics, including potency, target engagement, internalization, and stability assays.
• Analyze data with appropriate statistics (GraphPad Prism, Excel), and present results and interpretation at project team meetings.
• Write and maintain assay protocols, and accurate, detailed records in an electronic lab notebook (ELN).
• Maintain safe and efficient lab operations, including inventory, reagent management, and equipment upkeep.

Skills

Cell culture

qPCR

Western blot

ELISA/MSD

Data analysis

ELN documentation

Education

BS with 3+ years or MS with 1+ years in biology/related field

Tools

GraphPad Prism

ELN/LIMS

SoftMax Pro

Flow cytometry

MS Office

Job description

Salubris Biotherapeutics, Inc. is seeking a Senior Research Associate to support discovery and preclinical characterization of novel biologics for CVM diseases. You will independently execute cell-based and molecular assays in disease-relevant models and contribute data driving candidate selection.

Collaborative team environment in a fast-paced biotech setting. The role emphasizes mammalian cell culture, qPCR, Western blot, and in vitro assays to profile potency, engagement, and stability of