Senior Bioinformatics Engineer - Oligonucleotide Drug Design

WuXi Biology; Natick (MA); On-site; USD 140,000 - 190,000; Full time

Job summary

WuXi Biology is seeking a Bioinformatics Engineer with experience in oligonucleotide drug design. You will apply bioinformatics tools to analyze gene expression, variations, and splicing to support target selection and design of oligo drugs.

Collaborate with wet lab teams and optimize workflows using Python, R, and Linux. Strong communication and collaboration across diverse teams are essential for project success.

Qualifications

• PhD in a relevant field with research focus in bioinformatics or related areas.
• 5+ years of experience in bioinformatics analysis or small nucleic acid drug development projects.
• Excellent written and spoken English; ability to communicate across multi-disciplinary teams.
• Familiarity with public databases (NCBI, Ensembl, UniProt) and data mining methods.
• Proficiency with tools like BLAST, Bowtie, SAMtools, DESeq2, STAR; scripting in Python or R.

Responsibilities

• Design and implement bioinformatics analyses for oligonucleotide drug discovery.
• Analyze gene expression, variations, and splicing to support target selection.
• Apply machine learning to oligo sequence design and optimize existing workflows.
• Read, write, and run Python, R, and Bash scripts; manage version control.
• Coordinate with wet-lab teams; present results and contribute to project discussions.
• Perform off-target analysis and interpret high-throughput sequencing data.

Skills

5+ years bioinformatics experience

Strong communication

Team collaboration

Learning and problem-solving

English/Chinese bilingual

Data mining mindset

Biostatistics understanding

ML in bioinformatics (preferred)

Education

PhD in bioinformatics / computational biology / molecular biology / genetics / CS / CADD

Tools

BLAST

Bowtie

SAMtools

DESeq2

Cufflinks

STAR

Python

R

Linux

Job description

WuXi Biology is seeking a Bioinformatics Engineer with experience in oligonucleotide drug design. You will apply bioinformatics tools to analyze gene expression, variations, and splicing to support target selection and design of oligo drugs.

Collaborate with wet lab teams and optimize workflows using Python, R, and Linux. Strong communication and collaboration across diverse teams are essential for project success.