Senior Bioconjugation Scientist - Process Scale-Up Leader

Ultimate Staffing; Fenton (MO); On-site; USD 85,000 - 125,000; Full time

Job summary

Ultimate Staffing is seeking a Senior Conjugation Scientist for a life sciences client in St. Louis, MO, onsite.

You will drive development and scaling of bioconjugation processes for fluorescent, enzymatic, and specialty-labeled proteins to support research, diagnostic, and commercial applications worldwide. Lead design of conjugation protocols, transfer from R&D to manufacturing, and cross-functional collaboration with analytical, purification, quality, and production teams.

Qualifications

• Bachelor's, Master's or PhD in chemistry, Biochemistry, Organic Chemistry, or a related scientific discipline
• Experience in protein chemistry, antibody conjugation, bioconjugation, or protein labeling
• Hands-on experience with protein purification techniques such as:
• FPLC
• HPLC
• SEC
• Dialysis
• Related purification methodologies
• Experience characterizing protein conjugates and analyzing process performance
• Strong problem-solving, troubleshooting, and analytical skills
• Ability to work independently while collaborating across multiple teams

Responsibilities

• Designing and optimizing chemical conjugation processes for antibodies, proteins, and peptides
• Developing robust protocols for fluorophore, enzyme, and specialty-label attachment
• Leading process transfer activities from R&D into manufacturing
• Optimizing reaction conditions, labeling efficiency, yield, stability, and overall process performance
• Troubleshooting technical challenges and implementing process improvements
• Overseeing lab-scale through production-scale conjugation and purification activities
• Collaborating with analytical, cell culture, purification, quality, and production teams
• Managing project timelines and serving as a technical lead for new product initiatives
• Supporting validation activities, process documentation, and compliance with quality systems
• Presenting project updates and technical findings to leadership

Skills

Protein chemistry

Bioconjugation

Antibody conjugation

Analytical skills

Troubleshooting

Independent work

Education

Bachelor's/Master's/PhD in chemistry/biochemistry/organic chemistry

Tools

FPLC

HPLC

SEC

Dialysis

Job description

Ultimate Staffing is seeking a Senior Conjugation Scientist for a life sciences client in St. Louis, MO, onsite.

You will drive development and scaling of bioconjugation processes for fluorescent, enzymatic, and specialty-labeled proteins to support research, diagnostic, and commercial applications worldwide. Lead design of conjugation protocols, transfer from R&D to manufacturing, and cross-functional collaboration with analytical, purification, quality, and production teams.