Senior Associate Scientist, Protein Sciences

Calico Life Sciences; South San Francisco (CA); On-site; USD 122,000 - 143,000; Full time

Job summary

An innovative research and development company is seeking a Senior Associate Scientist to join their Protein Sciences team. This role focuses on applying advanced biochemistry techniques and protein biophysical characterization to drive projects related to human aging and disease. The ideal candidate will work independently and collaboratively, utilizing a variety of experimental techniques to gain insights into protein interactions and potential therapeutics. With a commitment to scientific discovery and a vibrant drug-development pipeline, this position offers a unique opportunity to contribute to groundbreaking medical advancements in a supportive and dynamic environment.

Benefits

Annual cash bonuses

Qualifications

• 6+ years of industry experience in protein sciences and biochemistry.
• Proficient in biophysical assays and protein characterization techniques.

Responsibilities

• Apply biochemistry techniques to support projects on human aging.
• Collaborate with protein biochemists to understand protein targets.

Skills

Protein-small molecule binding characterization

Biophysical binding assays

Biochemical assays

Analytical techniques (Light scattering, LC-MS, HPLC)

Teamwork and communication

Education

BS/MS in Biochemistry

Tools

Biacore

Octet

ITC

TSA

Electronic notebook

Job description

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

Calico is seeking a Senior Associate Scientist to join our multi-disciplinary Protein Sciences team with a focus on applying biochemistry techniques, protein biophysical characterization and assay development to support projects relevant to human aging and disease. The candidate will work closely with protein biochemists to gain mechanistic understanding of protein targets and potential therapeutics. The ideal candidate must be highly motivated, detail-oriented, work autonomously with a variety of experimental techniques, and be comfortable presenting results to cross-functional teams.

Position Requirements:

• BS/MS in Biochemistry or related discipline, plus 6+ years post-graduate experience working in industry within a similar core function
• Experience with protein-small molecule binding characterization highly preferred
• Experience with high-mid throughput protein binding discovery screening highly preferred
• Strong expertise with protein based biophysical binding and competition assays (Biacore, Octet, ITC, TSA, etc.) and proficiency in handling related instruments
• Experience with biochemical and/or biophysical assays in 96- or 384- well formats is desired (ELISA, TR-FRET, Fluorescence Polarization, etc.)
• Experience with analytical techniques in protein biophysical characterization (Light scattering, LC-MS, HPLC)
• Experience using an electronic notebook
• Strong teamwork and proactive communication skills
• Independent, accountable, meticulous attention to detail, and able to multitask
• Strong communication and organizational skills to interact with collaborators
• Must be willing to work onsite five days per week

Nice to Have:

• Experience with protein purification (affinity, IEX and SEC) and assessing protein purity using SDS-PAGE
• Experience with enzymatic assays and data interpretation
• Experience with protein labeling and conjugation chemistries
• Experience with assay development and automation/liquid handlers

The estimated base salary range for this role is $122,000 - $143,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.