Senior Associate Scientist, Metabolomics

Calico Life Sciences; South San Francisco (CA); On-site; USD 107,000 - 143,000; Full time

Job summary

A leading life sciences company in South San Francisco is seeking a Senior Associate Scientist specializing in Metabolomics. The role focuses on investigating metabolic mechanisms of aging using advanced techniques in a collaborative research environment. Candidates should have a robust background in molecular biology, experience in laboratory settings, and the ability to manage multiple projects. This position offers a competitive salary, benefits, and the chance to contribute to groundbreaking research addressing human aging.

Benefits

Two annual cash bonuses

Qualifications

• 5+ years of relevant research experience.
• Proficiency in molecular biology methods.
• Experience with metabolic assays preferred.

Responsibilities

• Design and execute experiments related to metabolism.
• Analyze samples using LC-MS/MS.
• Conduct tissue culture and molecular biology techniques.

Skills

Mammalian cell culture

Gene editing techniques

Analytical skills

Attention to detail

Communication

Education

Bachelor's or Master's degree in molecular biology, cell biology, or biochemistry

Tools

LC-MS/MS

GraphPad Prism

R/Python

Job description

Senior Associate Scientist, Metabolomics

Join to apply for the Senior Associate Scientist, Metabolomics role at Calico Life Sciences

Senior Associate Scientist, Metabolomics

Join to apply for the Senior Associate Scientist, Metabolomics role at Calico Life Sciences

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Who We Are

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Who We Are

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description

Calico is seeking a highly motivated Senior Associate Scientist to join our team studying cellular and organismal metabolism. The successful candidate will play a key role in investigating metabolic mechanisms underlying aging and age-related disease using state-of-the-art metabolomics techniques, in both cell-based assays and in vivo mouse models. The ideal candidate will have strong technical expertise, excellent analytical skills, and the ability to work both independently and collaboratively in a dynamic research environment.

Responsibilities

• Design, plan, and execute experiments investigating cellular and organismal metabolism
• Prepare metabolomics and lipidomics samples from tissues, cells, and biofluids and analyze them by LC-MS/MS
• Conduct mammalian tissue culture and perform standard molecular biology techniques (e.g. nucleic acid extraction, western blot, ELISA)
• Assist with in vivo experiments, including handling/monitoring mice, tissue collection
• Analyze and interpret experimental data, prepare figures for, and present at internal meetings
• Maintain accurate and detailed laboratory records in compliance with institutional policies
  
  

Position Requirements

• Bachelor's or Master's degree in molecular biology, cell biology, biochemistry, or a related field, with 5+ years of post-Bachelor's (or 3+ post-Master's) relevant research experience in an academic or industry setting
• Proficiency in mammalian cell culture, gene editing techniques (CRISPR/Cas9, viral transduction) and basic molecular biology methods (e.g., nucleic acid extraction, Western blotting)
• Ability to manage multiple projects simultaneously and work independently
• Strong analytical skills and attention to detail
• Excellent communication and organizational skills
• Must be willing to work onsite five days a week
  
  

Nice To Have

• Experience with metabolic assays (e.g. Seahorse analysis) and flow cytometry
• Comfort with data analysis tools (e.g. GraphPad Prism, basic scripting in R/Python)
• Familiarity with mass spectrometry methods (LC-MS, GC-MS) is a plus
• Previous involvement in manuscript preparation or authorship of peer-reviewed publications
  
  

The estimated base salary range for this role is $107,000 - $143,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Seniority level

• Seniority level

  Not Applicable

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

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