Senior Associate Scientist In vitro Biology Neuroscience Discovery

1010 Celgene - Summit (Corp); Cambridge (MA); On-site; USD 105,000 - 127,000; Full time

Job summary

Bristol Myers Squibb is seeking a Senior Associate Scientist in vitro biology for neuroscience discovery in Cambridge, MA. You will develop disease-relevant iPSC-based models and advanced cellular assays to understand target biology and disease mechanisms, contributing to translational pharmacology and program progression.

Independent experimentation, cross-functional collaboration, and rigorous data interpretation are essential.

Qualifications

• Bachelor's with 4+ years or Master's with 2+ years in neuroscience, biology, molecular biology, or a related discipline.
• Strong foundation in molecular and cellular biology with experience designing and executing experiments.
• Experience developing cellular assays for target validation and pharmacological profiling.
• Hands-on experience with human iPSC-derived neural and/or glial models.

Responsibilities

• Design and execute hypothesis-driven studies to investigate novel therapeutic targets in neurodegenerative disease.
• Develop and apply advanced human iPSC-based models and disease-relevant assays to evaluate target biology and therapeutic potential.
• Design, optimize, and implement mechanistic and translational assays that enable target interrogation, in vitro pharmacological characterization, compound profiling, and progression of drug-discovery programs.
• Establish causal relationships between target modulation and disease-relevant mechanisms using genetic, pharmacological, and molecular approaches.
• Support structure-activity relationship (SAR) efforts by generating high-quality in vitro pharmacology data that inform compound optimization, mechanism-of-action studies, and program progression.
• Represent Discovery Biology on cross-functional program teams, presenting experimental results and biological interpretation to support program progression.

Skills

Molecular biology

Cell biology

Neuroscience

Data interpretation

Experiment design

Education

Bachelor's or Master's in neuroscience/biology

Tools

iPSC culture

Cell-based assays

Job description

At Bristol Myers Squibb, our employees often ask, "Who are you working for?"—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Senior Associate Scientist – In vitro Biology, Neuroscience Discovery

The Neuroscience TRC is committed to discovering and developing new therapies for patients with neurodegenerative and neuromuscular diseases. Our research combines human disease biology, molecular and cellular neuroscience, and target validation to identify and advance promising therapeutic opportunities. We are seeking a creative and rigorous scientist to investigate novel therapeutic targets and build confidence in their relevance to neurodegenerative disease. The successful candidate will develop and apply disease-relevant assays and advanced human iPSC-based models to understand how genetic or pharmacologic target modulation influences disease biology. This role is ideal for a scientist with strong molecular and cellular biology expertise, a passion for understanding disease mechanisms, and experience translating biological questions into meaningful therapeutic hypothesis. The ideal candidate will have experience developing disease-relevant cellular assays and applying advanced human iPSC-based models to investigate target biology. Experience with microglia, neuroimmune biology, or multicellular CNS models is highly desirable.

Position Responsibilities

• Design and execute hypothesis-driven studies to investigate novel therapeutic targets in neurodegenerative disease.
• Develop and apply advanced human iPSC-based models and disease-relevant assays to evaluate target biology and therapeutic potential.
• Design, optimize, and implement mechanistic and translational assays that enable target interrogation, in vitro pharmacological characterization, compound profiling, and progression of drug-discovery programs.
• Establish causal relationships between target modulation and disease-relevant mechanisms using genetic, pharmacological, and molecular approaches.
• Support structure-activity relationship (SAR) efforts by generating high-quality in vitro pharmacology data that inform compound optimization, mechanism-of-action studies, and program progression.
• Represent Discovery Biology on cross-functional program teams, presenting experimental results and biological interpretation to support program progression.

Basic Qualifications

• Bachelor's degree with 4+ years of academic and/or industry experience or Master's degree with 2+ years of academic and/or industry experience.
• Degree in neuroscience, biology, molecular biology, cell biology, or a related discipline.
• Strong foundation in molecular and cellular biology, with experience designing and executing experiments to address biological questions.
• Experience developing and applying cellular assays for target validation, pharmacological characterization, and/or compound profiling.
• Hands-on experience with human iPSC-derived neural and/or glial models and their application to neurodegenerative disease research.
• Demonstrated ability to independently drive experiments from conception through data interpretation and clearly present scientific findings within multidisciplinary teams.

Preferred Qualifications

• Strong understanding of neurodegenerative disease biology, including pathways related to mitochondrial function, neuroinflammation, lipid and lysosomal biology, and protein homeostasis.
• Experience developing and applying robust cellular assays for target validation, pharmacological characterization, or compound profiling.
• Experience with disease-relevant cellular models and phenotypic endpoints applicable to neurodegenerative disease.
• Industry experience supporting target validation, in vitro pharmacology, or drug-discovery programs is beneficial.

Compensation Overview

Cambridge Crossing: $105,040 - $127,287

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully - carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans - including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs.

Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

For roles based in Washington State only: If you live in or expect to work from Washington State if hired for this position, please visit this page for important information about the Washington Fair Chance Act.

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

We're creating innovative medicines for patients fighting serious diseases. We're also nurturing our own diverse team with inspiring work and challenging career options. No matter the role, each one of us makes a contribution. And that makes all the difference.