Senior Associate Scientist (HPLC)

R&D Partners; San Carlos (CA); On-site; USD 159,802,000 - 177,710,000; Part time

Benefits offered by this job

Medical insurance PPO/HMO/HSA

401k plan

Employee Assistance Program

Long-term disability

Weekly payroll

Online timecard approval

Job summary

R&D Partners is seeking a Senior Associate Scientist in San Carlos, CA to develop robust conjugation processes for polysaccharide-protein conjugates. You will perform synthesis, purification, and characterisation, optimize procedures, and troubleshoot with minimal guidance.

You will design DOE experiments, analyze vendor materials, and maintain strict SOP adherence while collaborating across teams in a fast-paced environment.

Qualifications

• BS in Chemistry/Biochemistry with 5+ years in industry, or MS with 3+ years.
• Experience setting up chemical reactions.
• Protein conjugation and purification experience is a major plus.
• Dialysis, diafiltration, SEC, and TFF experience.

Responsibilities

• Generate conjugates and purify them using SEC and TFF.
• Design DOE-based process development experiments.
• Analyze vendor samples with colorimetric assays, gels, and LC.
• Maintain rigorous documentation and notebooks.
• Support lab operations and instrument maintenance.
• Present results in group meetings and cross-functional projects.

Education

BS in Chemistry/Biochemistry with 5+ years in industry

MS in Chemistry/Biochemistry with 3+ years in industry

Tools

HPLC

UPLC

OpenLab/ChemStation

Waters Empower

Job description

We are hiring a Senior Associate Scientist to support the development of a robust process for conjugate vaccine development. The candidate will bring proficiency in conjugation techniques and advance the Conjugation Development team's wider goal through hands-on experimentation and analysis of vendor-supplied materials. Specifically, this will include synthesis, purification, and analytical characterization of polysaccharide-protein conjugates. With the training provided, the successful candidate will be expected to optimize and troubleshoot the synthesis and purification procedures independently with minimal guidance.

This is a 12-month contract position based in San Carlos, CA.

Responsibilities

• Generate conjugates using various conjugation techniques and purify them using size-exclusion chromatography and tangential flow filtration (TFF), among other methods.
• Design and execute process development experiments using Design of Experiments (DOE) with minimal guidance.
• Conduct analyses of vendor-supplied samples using colorimetric assays, gel electrophoresis, and liquid chromatography while strictly adhering to established SOPs.
• Review analytical assay data for accuracy and adherence to SOPs.
• Maintain good documentation practices for recording experimental plans and results in an electronic lab notebook and associated reports.
• Maintain organized records of the review status of notebook entries and analytical data.
• Participate in group meetings to present work, interpret data, and report results accurately.
• Support lab operations.
• Assist with instrument maintenance, including troubleshooting and ordering supplies.
• Contribute to reports, certificates, and other documentation supporting process development.
• Collaborate effectively with team members and contribute to cross-functional activities.

Qualifications

• BS degree in Chemistry, Biochemistry, or related field with a minimum of 5 years of industry experience, or MS degree with a minimum of 3 years of industry experience.
• Other combinations of education and/or experience may be considered.
• Experience setting up and carrying out chemical reactions.
• Experience with protein conjugation reactions is a major plus.
• Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, size-exclusion chromatography, and tangential flow filtration (TFF).
• Experience in an analytical development or quality control (QC) role is a plus.
• Prior experience running colorimetric assays is required.
• Prior experience with HPLC is required.
• Prior experience with SDS-PAGE is required.
• Direct experience operating Agilent HPLC using OpenLab/ChemStation software and/or Waters UPLC and Empower software for data acquisition and analysis is a plus.
• Critical thinking and ability to analyze data.
• Excellent attention to detail, organizational skills, and record-keeping abilities.
• Strong interpersonal skills and ability to communicate effectively with team members.
• Ability to work both independently and collaboratively in a fast-paced environment.
• Commitment to integrity, professionalism, and safety in all aspects of work.

Pay

• $56-$62/hr

Why Choose R&D Partners?

As an employee, you have access to a comprehensive benefits package including:

• Medical insurance – PPO, HMO & HSA
• 401k plan
• Employee Assistance Program
• Long-term disability
• Weekly payroll
• Online timecard approval

R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.

R&D Partners is an equal-opportunity employer.