Associate Scientist II, Bioanalytical Sciences

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 90,000 - 120,000; Full time

Job summary

Alnylam Pharmaceuticals in Cambridge, MA is seeking an Associate Scientist II in Bioanalytical Sciences to specialize in ligand-binding assays and immunoassays for quantifying oligonucleotides, proteins, peptides, and antibodies. You will perform high-quality sample analysis using established methods to inform PK/PD endpoints across preclinical species.

The role emphasizes precise bench work, meticulous record-keeping, and collaboration with cross-functional teams.

Qualifications

• Bachelors or degree in a scientific discipline with 1‑3 years of relevant laboratory experience or Master degree with 1 year of relevant laboratory experience.
• Hands‑on molecular laboratory experience with ELISA, Western blotting, and qPCR.
• Strong pipetting and bench technique with reproducible data across large sample sets.
• Meticulous record keeping and organization are essential.
• Ability to manage multiple projects in a fast‑paced team.

Responsibilities

• Perform high‑throughput ligand‑binding assays and immunoassays to support PK/PD assessments.
• Execute end‑to‑end sample analysis workflows with QC and data processing.
• Maintain electronic lab notebook records and organize raw data for review.
• Contribute to workflow efficiency and assay transfers; troubleshoot when needed.
• Communicate status and timelines to supervisors and study teams.

Skills

Ligand-binding assays

Immunoassays

ELISA

Western blot

qPCR

Pipetting

Excel

GraphPad Prism

SoftMax

Discovery Workbench

Education

Bachelor's degree

Master's degree

Tools

ELISA

Western blot

qPCR

Job description

Associate Scientist II, Bioanalytical Sciences

Cambridge, MA

Overview

The Bioanalytical Sciences group at Alnylam is seeking a highly motivated Associate Scientist II specializing in ligand-binding assays and immunoassays for the quantification of oligonucleotides, proteins, peptides, and antibodies. This individual will focus on high-quality sample analysis using established methods, generating reliable data to inform drug exposure, target engagement, pharmacodynamic (PD) responses, and biomarker endpoints across preclinical species and biological matrices, supporting the advancement of RNAi therapeutics.

The ideal candidate takes pride in executing assays with precision, can manage large sample sets efficiently, and maintains meticulous records. They will have a background in biochemical, pharmaceutical, or biological sciences, strong hands‑on bench skills, and exceptional attention to detail. This individual will thrive in a fast‑paced, goal‑oriented environment. This is an exciting opportunity to join a vibrant team and interact with highly motivated scientists across a broad array of disciplinary expertise areas.

This position is onsiteand will be primarily located in Cambridge, MA.

Key Responsibilities

• Perform routine, high‑throughput, non‑GLP sample analysis using established ligand‑binding assays (ELISA, hybridization ELISA, MSD, Quanterix, and ELLA) and immunoassays (Western blot and Jess) to support pharmacokinetic (PK), target engagement, and pharmacodynamic (PD) assessments across a variety of biological matrices.
• Execute end‑to‑end sample analysis workflows, including sample organization and reconciliation, sample preparation and tissue homogenization, plate layout, assay execution, data processing, and quality control (QC) review, in accordance with established methods and study plans. Apply assay acceptance criteria to standard curves and quality controls; identify and flag failed runs, outliers, and trends; and perform repeat analyses as needed.
• Maintain accurate, contemporaneous electronic laboratory notebook (ELN) records and organize raw data, analysis files, and results to ensure they are traceable, review‑ready, and readily accessible to the team.
• Maintain appropriate procedures and controls to ensure consistent assay performance and reproducible data.
• Communicate sample status, timelines, and data to the supervisor and study teams; prioritize multiple studies to meet timelines program deliverables.
• Contribute to workflow efficiency through batching, automation, and standardized templates, and support assay transfers or bridging as needed.
• Learn in‑depth knowledge about the technologies and platforms used to generate results to help troubleshoot, address queries, and present data to diverse groups within.

Qualifications

• Bachelors or degree in a scientific discipline with 1‑3 years of relevant laboratory experience or Master degree with 1 year of relevant laboratory experience.
• Hands‑on molecular laboratory experience with techniques such as ELISA, Western blotting, and qPCR.
• Strong pipetting and bench technique with demonstrated ability to generate reproducible data across large sample sets.
• Highly organized and detail‑oriented, with meticulous record keeping practices.
• Ability to manage multiple projects effectively in a fast‑paced team environment.
• Proficiency in Excel, Word, and PowerPoint.
• Experience with additional analytical software, such as GraphPad Prism, SoftMax, or Discovery Workbench, is preferred.
• Clear verbal and written communication skills, with the ability to collaborate effectively across teams.

About Alnylam

We are the leader in RNAi therapeutics– a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize‑winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what’s possible. Our deep pipeline, late‑stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E‑Verify Employer.

The pay range below reflects the full‑time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short‑term incentive award (e.g., bonus or sales incentive) and an annual long‑term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well‑being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company‑wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well‑being reflects our belief that caring for our people fuels the impact we create together.