Senior Associate Scientist, Biology

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 80,000 - 120,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Life and disability insurance

401(k) with company match

Paid time off and wellness days

Job summary

Alnylam Pharmaceuticals in Cambridge is seeking a Senior Associate Scientist to join their Research department. The successful candidate will support the development of therapeutic programs and work on RNAi compounds targeting metabolic diseases. Ideal qualifications include a B.S. in life sciences with significant lab experience, particularly in RNA analysis and working with rodent models.

This full-time position offers a competitive salary ranging from $80,000 to $120,000 annually, accompanied by a robust benefits package that includes health coverage, paid time off, and a 401(k) plan.

Qualifications

• Minimum B.S. degree in a life sciences-related discipline with 4+ years of experience.
• Proficiency in RNA/DNA/protein analysis techniques.
• Cell/tissue culture experience and basic rodent in vivo skills.
• Experience in running obese rodent disease models is highly desired.

Responsibilities

• Contribute to study design and execution to characterize RNAi therapeutic programs.
• Develop and conduct assays that support in vivo studies.
• Perform in vitro procedures and analyze data.
• Prepare experimental reports and present data.

Skills

RNA/DNA/protein analysis techniques

Cell/tissue culture experience

Rodent in vivo skills

Lab research experience

Experimental design knowledge

Education

B.S. in Molecular Biology, Cell Biology, or Genetics

M.S. in a life sciences-related discipline

Tools

ELISA

Western blot

qPCR

Job description

Overview

We are seeking a talented candidate to fill an Senior Associate Scientist position within Alnylam's Research department. This position is an opportunity to potentially see one's work progress from the bench to the clinic and positively impact patients' lives with metabolic diseases. The successful candidate will support early development of potential therapeutic programs as part of a multidisciplinary team and be involved in the discovery of RNAi compounds for a indications related to obesity, diabetes and other rare metabolic conditions. The successful candidate will have background in biological sciences and be technically skilled in basic molecular biology techniques and work with rodent species. Responsibilities will include designing, developing, and executing studies in rodent obesity models using small interfering RNAs (siRNAs) and conducting the associated in vitro molecular-based assays such as qPCR, western blots, and ELISAs. Passion for science, a desire to learn new techniques, as well as experience and willingness to work with rodents are a must!

Key Responsibilities

• Contribute to study design and execution of studies to characterize molecules for RNAi therapeutic programs, including rodent metabolic disease models
• Develop and conduct assays such as qPCR, western blot, and ELISA, that support in vivo studies
• Perform in vitro and cell-based assays to characterize drug activity
• Perform in vivo procedures in rodents, including administration of therapeutics via established methodologies
• Analyze and interpret the data
• Prepare clearly articulated experimental reports and data presentations
• Prepare of SOPs/protocols
• Present data to groups within and outside of Research

Qualifications

• Minimum B.S. degree in a life sciences-related discipline such as Molecular Biology, Cell Biology, or Genetics with 4+ years of experience in laboratory research or a M.S. degree with 2+ years of experience in laboratory research
• Proficiency in RNA/DNA/protein analysis techniques, including ELISA, western blotting and qPCR
• Cell/tissue culture experience
• Basic rodent in vivo skills (animal handling, subcutaneous/intravenous dosing, blood collection, and necropsy/dissection expertise) is highly desired
• Experience setting running obese rodent disease models is highly desired
• Ability to perform and troubleshoot assays independently or with limited direction of supervisor(s)/project leader(s)
• Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions and generate clear reports
• Must be flexible, open to new tasks and challenges and able to work on tight deadlines
• Proven ability to work in a team environment and across functional areas
• Cover letter encouraged

U.S. Pay Range

$80,000.00 - $120,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.