Senior Associate Director, Translational Toxicology

Wave Life Sciences; Boston (MA); On-site; USD 170,000 - 230,000; Full time

Job summary

Wave Life Sciences in Lexington, MA, seeks a senior scientist to lead preclinical safety assessments and regulatory interactions for oligonucleotide therapies. You will shape safety strategies across discovery and development, guiding toxicology study design, risk mitigation, and cross-functional collaboration.

The role requires 7+ years in preclinical safety, a PhD in biology/toxicology, and strong GLP/regulatory expertise, with travel to CROs and project teams as needed.

Qualifications

• DVM/PhD or PhD in biology, toxicology or related field, Board certification in toxicology is highly desirable.
• Relevant experience (7+ years) in preclinical safety assessment of novel therapeutic entities.
• Experience with regulatory submissions and responses.

Responsibilities

• Serve as a primary representative of PCDS on Program Teams.
• Coordinate between PCDS and CMC, Regulatory Affairs, Clinical Operations, and Discovery Sciences.
• Provide risk assessment and de-risking strategies for discovery programs.
• Design preclinical strategies for Development candidate molecules.
• Coordinate toxicity studies with outsourcing and integrate bioanalysis and toxicokinetics into studies.
• Lead the interpretation of animal model data for efficacy/tolerability and PK/PD.
• Guide projects and senior management on toxicology conclusions and strategic impact.
• Lead issue-resolution teams for investigative toxicology and discovery work.

Skills

GLP compliance

Toxicology leadership

Regulatory submissions

Communication skills

Team leadership

Travel readiness

Education

PhD in biology/toxicology

DVM/PhD (optional)

Board certification in toxicology (desirable)

Job description

Wave Life Sciences in Lexington, MA, seeks a senior scientist to lead preclinical safety assessments and regulatory interactions for oligonucleotide therapies. You will shape safety strategies across discovery and development, guiding toxicology study design, risk mitigation, and cross-functional collaboration.

The role requires 7+ years in preclinical safety, a PhD in biology/toxicology, and strong GLP/regulatory expertise, with travel to CROs and project teams as needed.