Senior Scientist, Toxicology

AIRNA; Cambridge (MA); On-site; USD 90,000 - 120,000; Full time

Job summary

AIRNA is seeking a highly motivated Senior Scientist in Toxicology to drive pre‑clinical safety strategies for oligonucleotide programs. The role involves providing scientific leadership and serving as Study Director for toxicology studies while managing internal and external teams to ensure high quality execution.

The ideal candidate holds a PhD in toxicology or pharmacology with extensive industry experience, particularly in non‑clinical development programs for antisense oligonucleotides. This position is based in Cambridge, MA.

Qualifications

• PhD degree in toxicology, pharmacology or related disciplines with a minimum of 3 yrs of relevant industry experience.
• BS/MS degree and DABT (preferred) with 10 years of relevant experience.
• Experience with non‑clinical development programs for antisense oligonucleotides or siRNA.
• Knowledgeable about GLP policies and regulatory nonclinical testing requirements.
• In-depth familiarity with ICH, FDA and other regulatory guidance.
• Experience managing CROs driving GLP/non‑GLP studies.
• Strong written and oral communication, interpersonal, and organizational skills.
• Initiative in producing high quality work in a start‑up environment.

Responsibilities

• Serve as Study Director for non‑GLP/GLP toxicology studies.
• Manage CROs, protocol development, and study execution.
• Act as SME for nonclinical safety issues.
• Prepare and review safety pharmacology and toxicology reports.

Skills

Toxicology expertise

Study director experience

Excellent communication skills

Project management

Education

PhD in toxicology or pharmacology

BS/MS degree

Job description

Job Description

AIRNA is seeking a highly motivated Senior Scientist in Toxicology to help drive the pre‑clinical safety strategy for the successful development of oligonucleotide programs across all stages of development. Reporting to the Head of Preclinical Development, this role will provide scientific leadership in toxicology and safety pharmacology across discovery and development project teams. Working cross‑functionally, the Senior Scientist will apply deep toxicology expertise to inform decision‑making across the drug development value chain. The individual will serve as Study Director, leading toxicology study operations and coordinating internal and external teams to ensure high‑quality, timely execution.

This position is based in Cambridge, MA.

Responsibilities

• Study Director for non‑GLP /GLP toxicology studies in rodent and non‑rodents.
• Managing CRO’s, protocol development and study execution.
• Serve as an SME related to nonclinical safety issues.
• Prepare and review written safety pharmacology and toxicology reports; and author the nonclinical document sections for regulatory submissions.

Qualifications

• PhD degree in toxicology, pharmacology or related disciplines with a minimum of 3 yrs of relevant industry experience.
• BS/MS degree and DABT (preferred) with 10 years of relevant experience.
• Experience with non‑clinical development programs for antisense oligonucleotides or siRNA.
• Knowledgeable about GLP policies and/or regulatory nonclinical testing requirements for pharmaceutical development.
• In depth familiarity with ICH, FDA and other regulatory guidance and regulations relevant to non‑clinical research.
• Experience managing CROs driving GLP/non‑GLP studies serving as a Study director.
• Excellent written and oral communication, interpersonal, and organizational skills.
• Initiative in producing high quality work products in a start‑up environment.