Senior Analytical Chemist - HPLC & Method Optimization

Eagle Analytical Services; Houston (TX); On-site; USD 65,000 - 105,000; Full time

Job summary

Eagle Analytical Services is seeking an Analytical Chemist II to perform advanced chemical analyses in a high-volume laboratory, with primary focus on HPLC, potency, and impurity testing. You will lead complex testing, provide technical guidance to junior staff, and ensure data integrity and regulatory compliance.

The role supports method validation, process improvements, and training initiatives, and requires a Bachelor’s degree in Chemistry or Biochemistry (Master’s preferred) plus 3–5 years

Qualifications

• Bachelor’s degree in Chemistry or Biochemistry; Master’s preferred.
• 3–5 years of experience in a regulated analytical laboratory (cGMP, cGLP, ISO 17025, USP, A2LA).
• Experience with sample preparative chemistry and wet chemistry analysis.
• Certified Pharmacy Technician (CPhT) a plus.
• Advanced proficiency with HPLC, UV-Vis, and other analytical instrumentation.
• Strong documentation and data integrity skills.

Responsibilities

• Perform routine and moderately complex chemical analyses, including HPLC, assay, potency, and impurity testing.
• Lead sample tracking, test execution, and result reporting, ensuring accuracy, completeness, and compliance.
• Independently identify, troubleshoot, and resolve unexpected test results or equipment issues.
• Conduct instrument maintenance, calibration, and advanced troubleshooting with minimal supervision.
• Review laboratory SOPs and contribute to their revision or creation; provide guidance to junior staff on SOP compliance.
• Ensure compliance with cGMP, cGLP, ISO 17025, USP, A2LA, and company SOPs.
• Participate in continuous improvement initiatives, method optimization, and high-volume workflow management.
• Train and mentor Analytical Chemist I and entry-level staff.
• Support internal audits, safety inspections, and client audits as needed.
• Assist with special projects, technical evaluations, and cross-functional laboratory initiatives.
• Communicate findings, trends, and recommendations effectively to laboratory and quality leadership.

Skills

HPLC

Assay

Potency testing

Impurity testing

SOP compliance

Data integrity

Troubleshooting

Mentoring

Communication

Instrumentation

Education

Bachelor's degree in Chemistry or Biochemistry

Master's degree preferred

Tools

HPLC instrumentation

UV-Vis

Job description

Eagle Analytical Services is seeking an Analytical Chemist II to perform advanced chemical analyses in a high-volume laboratory, with primary focus on HPLC, potency, and impurity testing. You will lead complex testing, provide technical guidance to junior staff, and ensure data integrity and regulatory compliance.

The role supports method validation, process improvements, and training initiatives, and requires a Bachelor’s degree in Chemistry or Biochemistry (Master’s preferred) plus 3–5 years