Scientist/ Research Associate - AI Protein Design

ZipRecruiter; Redmond (WA); On-site; USD 80,000 - 180,000; Full time

Job summary

A leading biopharmaceutical company located in Redmond is looking for a Protein Design Scientist or Senior Scientist. This individual will enhance and execute computational methods for protein design, work collaboratively on drug development, and apply expertise in macromolecular modeling. The ideal candidate is a PhD holder with significant experience in antibody development and protein modeling tools.

Benefits

Comprehensive benefits package

Opportunities for learning and growth

Qualifications

• 8+ years of experience using yeast libraries for protein binding or therapeutic antibodies.
• Expertise in antibody screening and development is highly desirable.
• Proven contributions to therapeutic antibody development.

Responsibilities

• Execute a computational design pipeline predicting properties of peptides and proteins.
• Collaborate with teams in Antibody Discovery and Protein Engineering.
• Analyze and present data to scientific and leadership teams.

Skills

Computational methods

Structural modeling

Protein prediction

Optimization

Education

PhD in bioengineering, biophysics, biochemistry, molecular biology, or cell biology

Tools

AlphaFold

RoseTTAFold

RFdiffusion

ProteinMPNN

Gromacs

MOE

Schrödinger

Job description

SystImmune Inc. is a clinical-stage biopharmaceutical company dedicated to developing innovative cancer treatments through breakthrough therapeutic multi-specific antibodies and antibody-drug conjugates (ADCs). With eight assets in ongoing clinical trials and a robust preclinical pipeline, we are seeking a talented Protein Design Scientist or Senior Scientist to join our AI drug design group.

Job Summary:

We are looking for a creative and motivated individual to execute and improve our Computational Protein Design pipeline using data-driven approaches to augment our first-in-class multi-specific biological programs. The ideal candidate will have experience applying computational methods to design novel peptides and proteins, with expertise in structural modeling, prediction, and optimization.

Essential Duties and Responsibilities:

• Execute a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody-based elements via data-driven approaches.
• Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display-based protein discovery platforms.
• Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process.
• Analyze, interpret, document, and present data to the scientific and leadership teams.
• Collaborate with our Antibody Discovery, Protein Engineering, and Immuno-oncology teams to contribute to the company's vision.

Qualifications:

• PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field.
• 8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies.
• Experience with relevant macromolecular modeling software (e.g., AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger).
• Expertise in screening and ranking of antibodies (ELISA, multi-parametric flow cytometry, BLI/OCTET).
• Proven contribution to therapeutic antibody development and selection is desirable; design and validation of novel biologically relevant antibodies are highly desirable.

Compensation and Benefits:

The hiring pay range for this position is $80,000 - $180,000 per year, based on skills, education, and experience relevant to the role.

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA, and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in discovery or IND-enabling stages, representing cutting-edge biologics development.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune provides a comprehensive benefits package.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.

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