Scientist – Oncology Drug Discovery (Cell-Based Assays)

The Fountain Group; Middleborough (MA); Presencial; USD 68 000 - 97 000; Tempo parcial

Resumo da oferta

The Fountain Group is seeking a lab-based Biologist for a 6-month contract onsite in Cambridge, MA. The role focuses on supporting small molecule drug discovery programs within Oncology, designing and executing experiments, and generating data to understand MOA and biomarker signals.

Responsibilities include developing cell-based assays, validating targets in preclinical models, and collaborating across disciplines to advance promising candidates.

Qualificações

• Bachelor’s or Master’s degree in biology or a relevant scientific field with 4-6 years post‑graduation research experience, or PhD with 2+ years post‑graduation research experience.
• Strong understanding of MOA and cellular responses to drug treatment.
• Hands‑on experience developing, performing, and troubleshooting cell-based assays.
• Experience with experimental design, data analysis, and interpretation in a laboratory research environment.
• Familiarity with molecular and cellular biology techniques such as Western blotting, ELISA, flow cytometry, RT-PCR, and high-content imaging.
• Experience working with cell lines, 2D/3D cell culture systems, or organoids is highly relevant.
• Ability to collaborate effectively with scientists across multiple disciplines and communicate scientific findings clearly.
• Experience in oncology research or small molecule drug discovery is highly desirable.

Responsabilidades

• Design and conduct experiments to investigate compound MOA, evaluate biological responses, and identify potential biomarkers.
• Develop, optimize, and troubleshoot cell-based phenotypic assays (2D/3D culture, clonogenic formats).
• Utilize techniques such as Western blotting, ELISA, flow cytometry, RT-PCR, and high-content imaging to support studies.
• Generate, analyze, and interpret data to understand compound behavior and targets in oncology.
• Present findings and communicate results with cross-functional project teams to support oncology programs.

Conhecimentos

MOA understanding

Cell-based assays

Experimental design

Data interpretation

Collaborative teamwork

Formação académica

Bachelor/Master in biology or related

PhD with 2+ years experience

Ferramentas

Western blotting

ELISA

Flow cytometry

RT-PCR

High-content imaging

Descrição da oferta de emprego

Details for the positionare as follows:

• 6-month contract to start with the strong possibility of extension or conversion depending on performance and business needs
• $60 hr
• Location: Cambridge, MA – 100% onsite
• Interview process: 1-hour virtual interview with a short scientific presentation and panel discussion
• Targeted Start date: November 16.

Job Description:

• We are seeking a highly motivated, lab-based Biologist to join a collaborative, cross-functional team supporting small molecule drug discovery programs within Oncology. This 6-month contract position will focus on advancing drug discovery projects from early research concepts toward clinical candidates.
• The ideal candidate will have strong hands‑on experience with cell-based assays, assay development, and an understanding of compound mechanisms of action (MOA). This individual will be responsible for designing and executing experiments, developing and troubleshooting assays, and generating and interpreting data to better understand oncology target biology, compound activity, and potential biomarkers.
• This role offers the opportunity to work across diverse oncology research projects and collaborate with scientists from multiple disciplines to support the identification and advancement of promising drug candidates.
• Oncology Target Biology: Validate oncology targets using preclinical models, including cell lines and organoids, and develop derivative models using genetic approaches.
• Cell-Based Assay Development: Develop, optimize, and troubleshoot cell-based phenotypic assays, including proliferation, survival, cell cycle, and apoptosis assays using 2D/3D culture systems and clonogenic formats.
• Experimental Design & Execution: Design and conduct experiments to investigate compound mechanisms of action (MOA), evaluate biological responses, and identify potential biomarkers.
• Laboratory Techniques: Utilize techniques such as Western blotting, ELISA, flow cytometry, RT-PCR, and high-content imaging to support experimental studies and biological characterization.
• Data Analysis & Interpretation: Generate, analyze, and interpret experimental data to assess compound behavior, understand biological mechanisms, and support drug discovery decisions.
• Scientific Communication & Collaboration: Present experimental findings and communicate results effectively with cross-functional project teams to support ongoing oncology research programs.
• Documentation & Record Keeping: Maintain accurate and organized experimental records in accordance with laboratory best practices, including generating high-quality data to support AI applications and deployment.

Required Skills:

• Bachelor’s or Master’s degree in biology or a relevant scientific field with 4-6 years post‑graduation research experience, or PhD with 2+ years post‑graduation research experience.
• Strong understanding of compound mechanisms of action (MOA) and cellular responses to drug treatment.
• Hands‑on experience developing, performing, and troubleshooting cell-based assays.
• Experience with experimental design, data analysis, and interpretation in a laboratory research environment.
• Familiarity with molecular and cellular biology techniques such as Western blotting, ELISA, flow cytometry, RT-PCR, and high-content imaging.
• Experience working with cell lines, 2D/3D cell culture systems, or organoids is highly relevant.
• Ability to collaborate effectively with scientists across multiple disciplines and communicate scientific findings clearly.
• Experience in oncology research or small molecule drug discovery is highly desirable.

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