Scientist, Non-Viral Delivery Process Sciences

Bristol Myers Squibb; Cambridge (MA); In loco; USD 128.000 - 156.000; Tempo pieno

Vantaggi offerti da questo lavoro

Flexible Time Off

11 paid holidays

Comprehensive benefits

Descrizione del lavoro

Bristol Myers Squibb in Cambridge, MA is seeking a Scientist, Non-Viral Delivery Process Sciences to advance scalable LNP-based delivery systems. You will join a multidisciplinary team spanning process development, analytical sciences, and product development to translate early mechanistic insights into development-ready manufacturing strategies.

The role emphasizes hypothesis-driven studies, scale‑up strategies, and robust characterization of targeting moieties.

Competenze

• Bachelor’s Degree or higher in Life Sciences or related fields.
• PhD preferred with extensive industry/research experience in delivery systems.
• Experience with design of experiments and data-driven process development.

Mansioni

• Design and execute hypothesis-driven studies to deepen mechanistic understanding for scalable LNP manufacturing.
• Develop end-to-end LNP processes including formulation, bioconjugation, purification, and downstream processing.
• Establish mechanistic understanding of targeting moieties and their impact on product quality.
• Create scale-down models to support process understanding and translation to larger scales.
• Apply DoE and analytical characterization to relate process attributes to performance.
• Collaborate with Analytical Development to enhance real-time process understanding.
• Evaluate emerging process technologies to improve efficiency, robustness, and manufacturability.
• Document findings and present results across cross-functional teams.

Conoscenze

Mechanistic process science

Cross-functional collaboration

Scientific communication

LNP formulation knowledge

Formazione

PhD in Life Sciences

Master’s Degree in Life Sciences

Bachelor’s Degree

Strumenti

LNP formulation equipment

Analytical methods (DLS, HPLC, LC/MS)

Process development tools

Descrizione del lavoro

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

The Cell Therapy Thematic Research Center is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next-generation, engineered cell-based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes.

Position Summary

We are seeking a highly motivated and technically driven Scientist, Non-Viral Delivery Process Sciences to join BMS’s Non-Viral Delivery team and help advance the next frontier in targeted delivery. This role brings together mechanistic process science, experimental innovation, and emerging technologies to build robust, scalable manufacturing strategies for complex non-viral delivery systems. Working at the interface of process science, advanced delivery technologies, and product development, you will make foundational contributions to a rapidly evolving platform and help translate targeted LNP science into scalable process technologies. The ideal candidate thrives in a highly collaborative, multidisciplinary environment and is energized by challenging conventional approaches, accelerating platform innovation, and translating promising scientific advances into development-ready drug products.

Position Responsibilities

• Design and execute hypothesis-driven studies to deepen mechanistic process understanding and enable robust, scalable manufacturing approaches for targeted LNP platforms.
• Develop and optimize end-to-end targeted LNP processes spanning formulation, bioconjugation, purification, and downstream processing, with a focus on scalability, manufacturability, and process robustness.
• Establish mechanistic process understanding of targeting moiety conjugation and incorporation and how these processes influence product quality attributes.
• Develop and apply fit‑for‑purpose scale‑down models to support process understanding, sensitivity analysis, and translation to larger‑scale manufacturing.
• Apply design of experiments, statistical analysis, and analytical, biophysical, and functional characterization to establish process–attribute–performance relationships.
• Partner with Analytical Development to evaluate and implement process analytical technologies to strengthen real‑time process understanding.
• Identify, evaluate, and implement emerging process technologies and experimental approaches that advance targeted LNP development and improve process efficiency, scalability, robustness, and manufacturability.
• Collaborate cross‑functionally across Research, Process Development, Analytical Sciences, CMC, and external partners to translate early process understanding into scalable, development‑ready manufacturing approaches.
• Document and communicate scientific findings through protocols, technical reports, presentations, and multidisciplinary forums.

Experience

Basic Qualifications

• Bachelor’s Degree
• 5+ years of academic and / or industry experience

Or

• Master’s Degree
• 3+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences
• No experience necessary

Preferred Qualifications

• PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biochemistry, or a related scientific discipline; or Master's degree with 3+ years or Bachelor's degree with 5+ years of relevant industry experience.
• Hands‑on experience with LNP formulation and relevant unit operations, including rapid mixing (e.g., microfluidic or impingement jet mixing), tangential flow filtration (TFF)/ultrafiltration-diafiltration (UF/DF), purification, or related downstream processing technologies.
• Experience with bioconjugation, surface functionalization, or related approaches for targeted delivery systems is desirable.
• Hands‑on experience with physicochemical and biophysical characterization of LNPs or related complex drug products using analytical techniques including particle sizing (DLS), zeta potential, UV-Vis and fluorescence spectroscopy, chromatography (e.g., HPLC, LC/MS), electrophoretic methods (e.g., SDS‑PAGE), or related approaches.
• Experience applying design of experiments (DoE), statistical or multivariate analysis, and other data‑driven approaches to process development and characterization.
• Demonstrated ability to work effectively in multidisciplinary teams and thrive in a highly collaborative, cross‑functional research environment.
• Strong technical communication skills, with the ability to present scientific findings and data clearly to multidisciplinary project teams and varied technical audiences

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Compensation Overview

Cambridge - MA - US $128,380 - $155,571

The starting pay range(s) listed above is for full‑time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https //careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https //careers.bms.com/ways-of-working.

Supporting People With Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information https //careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https //careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at [e-mail] the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.

R1607128 Scientist, Non-Viral Delivery Process Sciences