Scientist - LC-MS Bioanalytical

BioSpace; Thousand Oaks (CA); Presencial; USD 120.000 - 180.000; Jornada completa

Descripción de la vacante

Amgen is seeking a Scientist for LC-MS bioanalytical work in Thousand Oaks, CA. The role focuses on designing, validating, and implementing robust LCMS/MS methods for diverse modalities while supporting GLP preclinical and regulated clinical activities as needed.

The candidate will contribute to automation modernization and collaborate with multidisciplinary teams to improve throughput and data quality. Strong mentoring and communication skills are required.

Formación

• PhD or equivalent with pharma/biotech experience.
• Experience with LC-MS methods and regulatory bioanalysis.
• Strong background in sample preparation and LC-MS workflows.

Responsabilidades

• Plan, execute, and document LCMS/MS bioanalytical experiments.
• Develop and validate bioanalytical methods for small molecules and biomolecules.
• Analyze bioanalytical data from plasma, urine, CSF, and tissues.
• Prepare samples via protein precipitation, SPE, LLE, and affinity capture.
• Maintain accurate documentation in ELN and LIMS systems.
• Ensure regulatory compliance for GLP/GCP and submissions.
• Prepare and review study reports, SOPs, and memos.
• Communicate results to discovery and development teams and present findings.
• Support QC, time management, and cross-functional communication.
• Adhere to safety, training, and site procedures.
• Assist with lab housekeeping and operational support.

Conocimientos

Mass spectrometry

Bioanalytical data analysis

Project and time management

Cross-functional collaboration

Quality/regulatory awareness

Lab automation

Troubleshooting

Communication of results

Mentoring and supervision

Scientific problem-solving

Educación

Doctorate degree

Masters degree with 2 years experience

Bachelors degree with 4 years experience

Herramientas

KingFisher APEX/FLEX

Automated SPE systems

Robotic liquid handlers

QQQ mass spectrometry

HRMS

Descripción del empleo

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier live.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist - LC-MS Bioanalytical

What you will do

Lets do this. Lets change the world. This lab-based role supports the design, development, validation, and implementation of robust LCMS/MS bioanalytical methods for therapeutic modalities including small molecules, oligonucleotides, proteins, and other complex molecular entities. The initial focus is to expand discovery-stage support within PKDMBA, while maintaining flexibility to support GLP preclinical and regulated clinical activities as needed. The role will also contribute to modernization of automation and instrumentation to improve assay throughput and sensitivity, working closely with multidisciplinary research and development teams across Amgen.

Key Responsibilities Include

• Plan, execute, and document quantitative LCMS/MS bioanalytical experiments.
• Develop and implement fit-for-purpose bioanalytical methods with rapid turnaround.
• Perform small- and large-molecule bioanalysis in nonclinical and clinical matrices, including plasma, urine, CSF, and tissues.
• Prepare biological samples using protein precipitation, solid-phase extraction, liquidliquid extraction, affinity capture, and related techniques.
• Organize, analyze, interpret, and present bioanalytical data with strong attention to data integrity and fidelity.
• Maintain complete, accurate, and concise documentation in electronic laboratory notebooks and other laboratory systems.
• Ensure data and records meet applicable regulatory expectations for global submissions and remain current with relevant industry guidance.
• Author and review study reports, analytical methods, SOPs, technical memos, and other regulatory-compliant documents.
• Communicate bioanalytical results to discovery and development teams; contribute to publications and present findings at scientific meetings.
• Support report quality control, effective time management, and clear cross-functional communication.
• Follow all safety, training, documentation, and site-specific procedural requirements.
• Perform routine laboratory housekeeping and operational support activities as needed.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek is a key contributor with these qualifications.

Basic Qualifications

• Doctorate degree
• Or
• Masters degree and 2 years of relevant industrial/technical experience
• Or
• Bachelors degree and 4 years of relevant industrial/technical experience

Preferred Qualifications

• Prefer Bachelor's or Master's experience
• Prior experience in CRO or pharma/biotech strongly desired
• Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms as well as HRMS
• Experience with an array of analytical technologies that can accelerate bioanalysis inclusive of automation and/or micro-sampling
• Prior GLP and GCP experience.
• Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, serum, tissues, cerebrospinal fluid).
• Hands-on experience with automated or semi-automated sample preparation for LC-MS bioanalysis, including protein precipitation, SPE, affinity capture, and other high-throughput workflows, using platforms such as KingFisher APEX/FLEX, automated SPE systems, and robotic liquid handlers.
• Prior experience in bioanalytical (regulated) assay execution and transfer to CROs
• Must be willing to work in a fast-paced, multi-project environment with high workload demands, and consistently deliver high-quality results within established timelines.
• Demonstrated ability to resolve scientific challenges efficiently and prioritize effectively
• Excellent scientific problem-solving skills
• Excellent project and time management abilities
• Ability to work collaboratively with internal and external stakeholders
• Supervisory and mentoring experience in a lab-based setting

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

• The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
• In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include
• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

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Sponsorship

Sponsorship for this role is not guaranteed.

Equal Opportunity Statement

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.