Scientist, Large Molecule Analytical (On-site)

Merck; New Jersey; Presencial; USD 87.000 - 137.000; Jornada completa

Descripción de la vacante

Merck in Rahway, New Jersey, seeks a Scientist to solve complex analytical problems at the interface of biology, chemistry and informatics for biologics drug substances and products.

The role requires laboratory-based work, collaboration in a fast-paced, multidisciplinary team, and leadership in developing, qualifying, and transferring analytical methods for monoclonal proteins and related therapeutics. Strong communication and publication drive are valued.

Formación

• Bachelor or Master degree with pharmaceutical industry experience.
• Experience performing analytical method development and data interpretation.
• Ability to operate and troubleshoot analytical methods.
• Strong collaboration and communication across teams.

Responsabilidades

• Develop, qualify, implement and troubleshoot analytical methods for biologics.
• Transfer methods to manufacturing and participate in tech transfer.
• Author technical reports and support regulatory filings.

Conocimientos

Analytical Chemistry

Analytical Development

Biological Analysis

Biologics

Cell-Based Assays

DNA Extractions

GMP

Immunoassays

Laboratory Automation

LIMS

Laboratory Techniques

Mammalian Cell Culture

qPCR

SOP Writing

Educación

BA/BS in analytical chemistry/biochemistry or related field

MS with minimum 0+ year relevant experience

Herramientas

RLIMS

ELN

Empower

Descripción del empleo

Role Decription:

The Large Molecule Analytical department of our Research & Development Division is seeking applicants for a Scientist position. The Scientist is a laboratory-based scientific role tasked with solving complex analytical problems at the interface of biology, chemistry, and lab informatics disciplines to enable development of Biologics drug substances and drug products. The successful candidate must function well and be able to collaborate in a fast-paced, integrated multidisciplinary team environment. The qualified candidate will be responsible for development, qualification, implementation, troubleshooting and transfer of analytical methods for monoclonal proteins or other complex therapeutic proteins. Applicants must have effective organizational, multi-tasking, oral/written communications skills, show scientific leadership, and a desire to conduct research and publish. Evidence of strong cross-functional collaboration in an academic or industrial setting is also preferred.

Qualifications:

• Education:
  • BA/BS in analytical chemistry/biochemistry or related field with a minimum of 3 years of experience in the Pharmaceutical Industry, or
  • M.S. with a minimum of 0+ year relevant experience (with expected graduation no later than January 2027).
• Required Experience and Skills:
  • Prior experience in a laboratory environment
  • Ability to develop and apply basic principles and scientific concepts to execute work in a laboratory setting
  • Execute routine experiments and data interpretation with appropriate technical guidance
  • Ability to operate and troubleshoot analytical methods
  • Understanding of the fundamentals in separations science
  • Experience with UPLC/HPLC analysis of biologics (e.g., SEC, RP, IEX) and CE techniques or molecular biology (PCR, DNA extraction) and immunoassay (ELISA, gel electrophoresis) techniques
  • Ability to work within overall project timelines to manage prioritization and execution of individual deliverables with appropriate supervision
  • Demonstrated experience working within collaborative team environments
  • Experience in authoring and reviewing internal technical reports, sections of regulatory filings (e.g., IND, BLA) and external scientific publications
• Preferred Experience and Skills:
  • Past experience working as part of a project team
  • Strong knowledge of protein structure and degradation pathways
  • Experience in analysis of various Biologic modalities (e.g., mAb, antibody-drug conjugate, fusion protein)
  • Background in Analytical Methodologies and sound scientific understanding of Critical Quality Attributes/QbD/DOE principles
  • Prior experience with Microsoft Office and other research applications (e.g., RLIMS, ELN, Empower)
  • Experience in data analytics, programming, or laboratory automation

Required Skills:

• Analytical Chemistry
• Analytical Development
• Biological Analysis
• Biologics
• Cell-Based Assays
• DNA Extractions
• Good Manufacturing Practices (GMP)
• Immunoassays
• Laboratory Automation
• Laboratory Information Management System (LIMS)
• Laboratory Techniques
• Mammalian Cell Culture
• Real Time Polymerase Chain Reaction (qPCR)
• Standard Operating Procedure (SOP) Writing

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts

USA - New Jersey - Rahway

Where required by law, the compensation range for this role is provided below.

The salary range for the primary location of this role is: $87,300.00 - $137,400.00

This range reflects the Company's reasonable expectation of