Scientist, In Vivo CAR-T Therapy

BioSpace; Philadelphia (Philadelphia County); On-site; USD 108,000 - 132,000; Full time

Benefits offered by this job

Medical insurance

Vision insurance

Paid parental leave

401(k) retirement plan

Performance-based bonus

Equity

Job summary

Legend Biotech USA, Inc. in Philadelphia, PA is seeking a Scientist – In Vivo CAR-T Therapy to design, plan, and execute studies advancing cell and gene therapy pipelines, with a focus on in vivo CAR-T development from discovery through preclinical stages.

You will conduct in vitro and in vivo experiments, analyze data, and communicate findings through reports and presentations, collaborating across teams to translate concepts into therapeutic candidates.

Qualifications

• PhD in Immunology, Biology, Biochemistry, Chemistry or a closely related field.
• 2+ years of hands-on experience in cell and/or gene therapy research.
• Experience in designing and conducting in vivo CAR-T studies.
• Ability to prepare clear, detailed reports and communicate results.

Responsibilities

• Design, plan, and execute experimental studies to advance cell and gene therapy pipelines with in vivo CAR-T focus.
• Conduct and analyze in vitro and in vivo studies to evaluate potency, efficacy, and safety.
• Develop, optimize, validate, and troubleshoot assays and laboratory methods.
• Prepare high-quality technical reports, summaries, and presentations.
• Collaborate with internal teams to translate concepts into therapeutic candidates.

Education

PhD in Immunology, Biology, Biochemistry, Chemistry or related field

2+ years experience in cell/gene therapy research

Job description

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide. Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma. COMPANY: Legend Biotech USA, Inc JOB TITLE: Scientist – In Vivo CAR-T Therapy Job Duties The Scientist – In Vivo CAR-T Therapy will have the following duties: Design, plan, and execute experimental studies to advance cell and gene therapy platforms and pipeline programs, with a focus on in vivo CAR T development from early discovery through preclinical development. Conduct and analyze in vitro and in vivo studies to evaluate product potency, efficacy, and safety. Develop, optimize, validate, and troubleshoot experimental assays and laboratory methods, including cell line engineering, cell-based functional and cytotoxicity assays, ELISA and PCR-based assays, high-throughput binder screening, and viral vector packaging and titration. Analyze, interpret, and summarize complex scientific data generated from experimental studies and maintain accurate, complete, and well-organized experimental records and documentation. Prepare clear, detailed, and high-quality technical reports, summaries, and presentations to communicate research findings, experimental results, and scientific conclusions. Collaborate closely with internal research and early development teams in a cross-functional environment to support translation of novel scientific concepts into therapeutic candidates and advancement of cell and gene therapy research programs. Minimum Job Requirements Education Required: PhD in Immunology, Biology, Biochemistry, Chemistry or a closely related field. Experience Required: 2 yrs of experience in hands on experience in cell and/or gene therapy research. JOB SITE: 2300 Market St., 3rd Floor, Philadelphia, PA 19103 WORK HOURS: 9:00 a.m. to 5:00 p.m. 5 days 40 hr/wk SALARY: $119,692.00 per year The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws. Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles. Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work. Pay Range (Base Pay) $119,692 - $119,692 USD Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech. Work Authorization & Employment Eligibility Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates. EEO Statement It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances. Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. For information related to our privacy notice, please review: Legend Biotech Privacy Notice.