Scientist, Immune Engineering

AstraZeneca GmbH; Waltham (MA); On-site; USD 91,000 - 137,000; Full time

Benefits offered by this job

Market-driven base salary

Bonus eligibility

Long-term incentive

Generous paid time off

Health, dental, and vision coverage

Job summary

AstraZeneca is seeking an early-career Scientist to join the Cellular Resilience team in the United States, contributing to early discovery research at the intersection of gene delivery and cell therapy. The successful candidate will leverage their expertise in Immune cell engineering, functional assay development, and synthetic biology to help develop the next generation of cellular therapies.

Responsibilities include engineering cell lines and primary immune cells by viral and non-viral

Qualifications

• BS/MS with 5+ years or PhD with 0+ years in a relevant field including molecular biology, synthetic biology, Immunology, Biomedical engineering.
• Hands-on experience culturing and engineering established cell lines and primary human immune cells with viral or non-viral methods.
• Experience with immune functional assays such as cytotoxicity, co-cultures, proliferation, and cytokine measurement.

Responsibilities

• Engineer cell lines and primary immune cells using viral and non-viral techniques.
• Develop high-throughput in vitro cellular assays with multicolor flow cytometry, plate readers, ELISA/MSD, qPCR.
• Analyze complex data and present results to internal and external stakeholders.

Skills

Immune cell engineering

Functional assay development

Synthetic biology

Molecular biology

Multicolor flow cytometry

Education

BS/MS with 5+ years or PhD with 0+ years in molecular biology / immunology / bioengineering

Tools

Flow cytometry

Lentivirus / AAV / LNP

qPCR / ELISA / MSD

Job description

We are seeking an early-career Scientist to join the Cellular Resilience team to contribute to groundbreaking, early discovery research at the intersection of gene delivery and cell therapy. The successful candidate will leverage their expertise in Immune cell engineering, functional assay development, and synthetic/molecular biology to develop the next generation of cellular therapies.

Key Responsibilities:

• Engineering cell lines and primary immune cells by viral and non-viral techniques

• In-vitro cellular assay development with an emphasis on high-throughput readouts such as multicolor flow cytometry, plate reader, ELISA/MSD, qPCR

• Analyze and interpret complex experimental data, present findings to both internal and external stakeholders

Qualifications:

• BS/MS with 5+ years or PhD with 0+ years of post-graduate experience in a relevant field including (but not limited to) molecular biology, synthetic biology, Immunology, Biological/Chemical/Biomedical engineering…etc

• Hands-on experience in the culture and engineering of established cell lines and primary human immune cells by viral and non-viral techniques such as lentivirus, AAV, LNP, electroporation…etc

• Hands-on experience with the execution and data analysis of immune functional assays including in vitro cytotoxicity, co-cultures, proliferation, and cytokine measurement

• Proactive, highly self-motivated, and thrives in a workplace where goals may shift

Preferred Qualifications:

• Experience with multi-color flow cytometry experiment design, acquisition, and analysis

• Experience with gene editing technologies (ie. CRISPR, TALE, Zinc Finger …etc) and evaluating gene editing outcomes (ie. Flow cytometry, qPCR, sanger sequence, NGS..etc)

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long-term incentive. We have a generous paid time off program and a comprehensive benefits package.

The annual base pay for this position ranges from $91,008.80 - $136,513.20. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted

10-Aug-2026

Closing Date

30-Aug-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.