Scientist III

Ivory Systems; Ridgefield (CT); On-site; USD 90,000 - 130,000; Full time

Job summary

Ivory Systems is seeking a hands‑on discovery research scientist to support cardiovascular‑renal‑metabolic programs with automated cell culture, NGS workflows, and organoid processes.

The role requires meticulous sample tracking, protocol adherence, and independent troubleshooting. Collaboration with genomics and automation teams is essential to advance target validation and discovery efforts.

Qualifications

• Experience in mammalian cell culture and cell biology required.
• NGS workflows including library preparation and QC expected.

Responsibilities

• Design, execute, and analyze cell‑based experiments supporting target validation and discovery.
• Operate and monitor automated workflows for cell‑based and molecular assays; troubleshoot issues.
• Perform tissue/cell/nuclei dissociation and execute various RNA sequencing workflows.
• Conduct molecular biology techniques (DNA/RNA extraction, PCR/qPCR, quantification).
• Maintain meticulous records and data integrity per SOPs and policies.
• Collaborate with cell biology, automation, genomics, and bioinformatics teams.

Skills

Mammalian cell culture

Cell biology

Cell-based assay execution

NGS workflow experience

Library preparation and QC

Laboratory automation platforms

Troubleshooting & documentation

Collaboration across groups

Education

Master’s degree + 3+ years

Bachelor’s degree + 7+ years

Equivalent education/experience

Tools

Sequencing instruments

PCR/qPCR techniques

Job description

The successful candidate will support discovery research programs within Cardiovascular-Renal-Metabolic Diseases through hands‑on operation of laboratory automation platforms, mammalian cell culture, cell-based assays, and functional genomics studies. The candidate will execute and monitor established automated cell culture and assay workflows and support automated iPSC‑derived kidney organoid processes and next‑generation sequencing (NGS)-related work, with platform‑and workflow‑specific training provided as needed.

The role requires reliable execution of automation and NGS workflows. Success requires exceptional attention to detail, careful sample and reagent tracking, precise adherence to established protocols, and independent troubleshooting of routine experimental or platform issues.

Duties & Responsibilities

• Design, execute, and analyze cell‑based experiments supporting target validation and discovery research, including routine mammalian cell culture, assay execution, image‑based analysis, and iPSC‑derived cell workflows.
• Operate and monitor established laboratory automation workflows for cell‑based and molecular assays, troubleshoot routine issues, and elevate complex problems appropriately.
• Perform tissue, cell, and nuclei dissociation and execute NGS workflows for bulk RNA‑seq, single‑cell RNA‑seq, single‑nucleus RNA‑seq, and related applications, including library preparation, quality control, quantification, normalization, sequencing setup, and sequencer operation.
• Perform routine molecular biology techniques, including DNA/RNA extraction, PCR and qPCR, nucleic acid and protein quantification, Western blotting, and basic sample preparation; analyze and interpret results, identify technical issues, and communicate findings and recommended follow‑up clearly.
• Maintain accurate sample, reagent, consumable, experimental metadata, and electronic laboratory notebook records while complying with SOPs, safety requirements, company policies, and data integrity standards.
• Collaborate across cell biology, automation, genomics, and bioinformatics groups.

Skills:

• Strong hands‑on experience with mammalian cell culture, cell biology, and cell‑based assay execution.
• Hands‑on NGS workflow experience, including tissue, cell, and/or nuclei dissociation, sequencing library preparation, quality control, and quantification for bulk RNA‑seq, single‑cell RNA‑seq, single‑nucleus RNA‑seq, or related applications.
• Some hands‑on experience with laboratory automation, automated instrumentation, or standardized high‑throughput workflows, with the ability and interest to develop further expertise in operating and troubleshooting automated cell‑based and molecular assays; automation programming is not required.
• Exceptional attention to detail and demonstrated ability to accurately execute lengthy, multi‑step protocols while maintaining sample integrity, data quality, and complete documentation.
• Ability to independently troubleshoot routine experimental or operational issues, communicate clearly, and work effectively in a collaborative research environment.

Desired Skills

• Experience running laboratory automation platforms for cell‑based or molecular assays.
• Experience with sequencing run setup and sequencer operation. Instrument‑specific operation can be trained when required.
• Experience with human induced pluripotent stem cell culture, differentiation, characterization, or iPSC‑derived cell assays.
• Experience with kidney organoid culture systems.

Education:

• Master’s degree with 3+ years of relevant experience; or
• Bachelor’s degree with 7+ years of relevant experience; or
• Equivalent combination of education and experience in cell biology, molecular biology, genomics, or a related scientific discipline.

No PhD applicants will be considered at this time.