Scientist II, Radiochemistry (preclinical)

Perceptive; Needham (MA); On-site; USD 65,000 - 121,000; Full time

Benefits offered by this job

Health benefits

Paid time off

401(k) plan

Life & disability insurance

Growth programs

Job summary

Perceptive in Needham, MA seeks a radiochemistry scientist to design, synthesize, purify, and formulate radiotracers for PET/SPECT imaging and preclinical studies. You will work with HPLC and TLC, manage multiple studies, and ensure compliance with safety standards for radioactive materials. Collaborate across teams and mentor junior staff while documenting results for reports, presentations, and publications.

The role offers career growth and a comprehensive benefits package. Ph.D.

Qualifications

• Ph.D. in Chemistry or a related field with 3+ years in academia or pharma labs.
• M.S. degree with 5+ years in a similar environment is acceptable.
• Experience handling radioactive materials safely and compliantly.
• Strong hands-on experience with radiochemistry labeling and analytics.

Responsibilities

• Execute and manage production of radiotracers for PET/SPECT imaging.
• Design, develop, and optimize radiolabeled compounds for preclinical studies.
• Synthesize radiopharmaceuticals and purify using HPLC/TLC methods.
• Prepare dose formulations and ensure release criteria for imaging studies.
• Collaborate cross-functionally and mentor junior team members.

Skills

Radiochemistry labeling

HPLC experience

TLC experience

Education

PhD in Chemistry

MS in Chemistry

Tools

HPLC

TLC

Job description

What can we offer you?Apart from job satisfaction, we can offer you:HEALTHMedical, Dental and Vision benefits for you and your family, including Flexible Spending Accounts (FSA)YOURSELFPaid time off policy including holidays and sick timeInternal growth and development programs & trainingsWEALTH401(k) program, life & accident insurance and disability insuranceThis role offers scientific expertise in reviewing, analyzing, and resolving challenges within the radiolabeling process. Responsibilities include the design and hands-on execution of synthesis, purification, and formulation of radiotracers for use in in vivo imaging, biodistribution, and efficacy studies. The scientist will collaborate closely with cross-functional teams and manage multiple studies simultaneously to support preclinical nuclear medicine programs.Key responsibilities include working safely and compliantly with radioactive materials and operating essential lab equipment such as HPLC and Radio-TLC.Key Responsibilities:Execute and manage the production of radiotracers used in PET/SPECT imaging and therapeutic research studies.Develop and validate:Contribute to the design, development, and optimization of radio labeled compounds targeting complex biological markers for application in PET/SPECT imaging and therapeutic studies.Synthesis of novel PET/SPECT and therapeutic radiopharmaceuticalsPurification methods for small and large moleculesAnalytical methods for HPLC and TLCRelease criteria for imaging studiesDose formulation processesOperate and maintain analytical and automated radiochemistry synthesis units.Stay current on advancements in radiochemistry and imaging through literature review and attendance at scientific conferences.Maintain clear, accurate, and up-to-date records.Analyze data, recognize aberrant results, and propose corrective actions or next stepsSummarize data for reports, papers, and presentations.Manage multiple projects simultaneously and prioritize tasks effectivelyMentor and guide junior team members.Provide scientific expertise and troubleshooting internally and in communication with Sponsors related to radiochemistry.Perform other duties as assigned.Functional Competencies (Technical knowledge/Skills)Experience with small and large molecule radiochemistry labeling, purification, and formulationWorking knowledge and experience with HPLC and TLC techniques in radiochemistryExperience in conjugation with chelators and labeling with radiometals is preferred.Prior experience with F-18 radiochemistry and radioiodination methods is considered advantageous.An effective team player with the ability to collaborate across various departmentsAbility to multi-task different projects and manage time effectivelyStrong written and verbal communication skills that can reach an audience of varying levels of expertiseExperience, Education, and CertificationsPh.D. in Chemistry or relevant field with 3+ years or M.S. with 5+ years of experience in an academic or pharmaceutical labExperience working with radioactive materials in a safe and compliant mannerAbility to lift more than 40 poundsProficient with Microsoft officeEnglish: FluentThis role is based in the Perceptive office/lab located in Needham, MA. The annual base salary range for this role is $65,305- $121,282. This range represents the anticipated initial annual salary and may vary depending on several factors including the candidate’s experience and skills and may be subject to market rate adjustment.