Scientist II, Bioinformatics (Applications Lab)

1000 Pacific Biosciences of California, Inc.; Menlo Park (CA); Vor Ort; USD 112.000 - 168.000; Vollzeit

Zusammenfassung

PacBio is seeking a Scientist II, Bioinformatics to join our Applications Lab, supporting production and proof-of-concept sequencing projects. You will develop computational infrastructure, automate data processing workflows, and deliver high-quality bioinformatics analyses for internal and customer projects.

This hands-on role requires strong programming skills, proficiency with Linux and high-performance computing, and the ability to troubleshoot complex problems.

Qualifikationen

• PhD in Bioinformatics or related field with experience; or a Master with 3-5 years experience or a B.S. with 5-7 years experience.
• Proficiency in Python programming and data processing.
• Strong Linux knowledge, shell scripting, and HPC experience.
• Experience with bioinformatics pipelines and NGS data analysis.

Aufgaben

• Bioinformatics analyses for internal and customer projects with robust deliverables.
• Maintain computational tools and infrastructure for lab operations.
• Develop and automate pipelines and workflows in Python and HPC environments.
• Collaborate with cross-functional teams to communicate results and insights.

Kenntnisse

Python

Linux

HPC

Data analysis

Troubleshooting

Documentation

Bioinformatics

Communication

Ausbildung

PhD in Bioinformatics

Masters with 3-5 years experience

B.S. with 5-7 years experience

Tools

Nextflow

AWS

SQL

Docker

Jobbeschreibung

Scientist II, Bioinformatics (Applications Lab) OPPORTUNITY

PacBio is advancing highly accurate long-read sequencing to enable new discoveries and applications in genomics research and genetic testing. We are seeking a Scientist II, Bioinformatics to join our Applications Lab and support production and proof-of-concept sequencing projects. This role will focus on developing and maintaining computational infrastructure, automating data processing workflows, and delivering high-quality bioinformatics analyses for internal and customer projects.

ABOUT THE ROLE

As Scientist II, Bioinformatics, you will be a member of PacBio's Applications Lab, an internal customer and services laboratory that supports product development, customer evaluations, and commercial opportunities.

You will be responsible for bioinformatics analyses for internal and customer projects, collaborating with laboratory scientists, Product Management, Marketing, and Sales teams to deliver results that demonstrate the capabilities and value of PacBio technology. You will also maintain the computational tools and infrastructure needed for laboratory operations, collaborating with laboratory scientists and Information Technology. This includes sample and project tracking, data organization, and automated analysis workflows. This is a hands-on role requiring strong programming skills, scientific expertise, and the ability to independently troubleshoot complex technical problems.

RESPONSIBILITIES

• Sequencing lab project support: Collaborate with laboratory scientists to support sequencing projects, ensuring reliable data processing, analysis execution, and timely delivery of results.
• Bioinformatics analysis: Analyze PacBio sequencing data for internal projects, customer evaluations, and proof-of-concept studies. Deliver accurate results, visualizations, and summaries to scientific and commercial stakeholders.
• Laboratory computational infrastructure maintenance: Maintain tools and infrastructure supporting laboratory operations, including sample and project tracking, and data organization.
• Pipeline development and automation: Develop, maintain, and troubleshoot bioinformatics pipelines and automated workflows using Python, Linux, and high-performance computing (HPC) environments. Reduce manual intervention and improve processing reliability.
• Scientific collaboration: Evaluate emerging bioinformatics methods and sequencing applications along with academic and commercial collaborators.

QUALIFICATIONS

• Required PhD in Bioinformatics, Computational Biology, Computer Science, Life Sciences, or a related field, and a minimum of 0-2 years related experience; may include post-doctoral experience.
• Alternatively, Masters with a minimum of 3-5 years of relevant experience or B.S. with a minimum of 5-7 years of related experience.
• Proficiency in Python programming, including data processing.
• Strong working knowledge of Linux, including command-line tools, shell scripting, and file system organization.
• Experience with high-performance computing (HPC) environments, including job schedulers, computational resource allocation, and pipeline execution.
• Familiarity with scientific development practices include testing, version tool, code review, workflow management frameworks (e.g. WDL, NextFlow), reproducible computational environments (containers), and code documentation.
• Experience with next-generation sequencing data analysis and bioinformatics pipelines.
• Strong analytical, troubleshooting, and organizational skills, with the ability to independently solve technical problems and manage multiple priorities.
• Excellent written and verbal communication skills, including the ability to document workflows and explain complex technical concepts to diverse audiences.
• Preferred Experience working in a sequencing facility, genomics core laboratory, or commercial sequencing service provider.
• Preferred Experience with laboratory operations, including sample tracking, metadata management, and project coordination.
• Preferred Experience analyzing PacBio HiFi or other long-read sequencing data.
• Preferred Experience with cloud-based data storage and analysis, particularly AWS.
• Preferred Experience with SQL and relational databases for managing and querying scientific data.
• Preferred Experience familiar with AI agentic software development tools like Claude Code or Codex.
• Preferred Experience in a customer-facing role.
• Preferred Experience communicating scientific results in conference presentations or peer-reviewed publications.

Candidates must have current authorization to work in the United States without the need for present or future sponsorship.

Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite. You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

Salary Range: $112,000.00 - $168,000.00

CORE VALUES

• BE CURIOUS. Our future depends on it.
• DELIGHT OUR CUSTOMERS. We strive to get it right every time.
• TAKE ACTION. We move fast and take calculated risks.
• EXECUTION MATTERS. Our customers rely on us.
• WORK TOGETHER. We care deeply about each other.

At PacBio, we’re all on a mission to enable the promise of genomics to better human health. It’s what fuels us every day. Our team is passionate about catalyzing scientists pursuing biological discoveries, and we’re looking for exceptional individuals like you to join us. If you’re interested at being at the intersection where health and technology come together, then consider joining our team. We look forward to meeting you.