Principal Cybersecurity Engineer

1000 Pacific Biosciences of California, Inc.; Menlo Park (CA); On-site; USD 196,000 - 294,000; Full time

Benefits offered by this job

Onsite workweek Mon–Thu

Friday work from home

Job summary

PacBio is seeking a Principal Cybersecurity Engineer to own security architecture across network, storage, HPC, and cloud environments. You will design controls, harden systems, and lead ISO 27001 certification efforts, with governance of SOX ITGCs and risk-based audits.

This senior individual contributor reports to the Head of Information Technology and collaborates with IT, R&D, software, operations, and finance to translate requirements into practical, verifiable controls.

Qualifications

• Extensive security architecture and ISO 27001 program experience.
• Hands-on risk assessment and SOX ITGCs across enterprise systems.
• Deep knowledge of network security, cloud/hpc security, and IAM.
• Experience with EDR and SIEM platforms and automation tools.

Responsibilities

• Own security architecture and multi-year engineering roadmap across enterprise, HPC, and cloud.
• Lead ISO 27001 program, risk assessments, controls evidence, and audits.
• Own SOX ITGCs including access, change control, and logging.
• Secure networks, data storage, and connected instruments across environments.
• Automate controls and evidence collection with code tooling.

Skills

Security architecture

ISO 27001 implementation

SOX ITGCs

Network security

HPC and cloud security

Identity and access management

Threat detection and response

Python/PowerShell/Bash

Infrastructure as code

Risk assessment

Security governance

Education

Bachelor's degree in Computer Science, Information Security, Engineering, or related field

12+ years of cybersecurity engineering experience; 5+ years as senior lead/architect

ISO 27001 implementation/certification experience

SOX IT general controls in a public company

Certifications such as CISSP, CISM, CCSP, ISO 27001 Lead Implementer/Lead Auditor

Tools

CrowdStrike

SentinelOne

Microsoft Defender

SIEM

Terraform

Ansible

CIS Benchmarks

Job description

Principal Cybersecurity Engineer PacBio | Menlo Park, CA | Onsite Opportunity

PacBio's long-read sequencing platforms help scientists and clinicians resolve genetically complex problems in human health, agriculture, and basic research. The information we protect, including human genomic data, proprietary chemistry and instrument designs, and the research of the customers who trust our platforms, is among the most sensitive that exists.

ABOUT THE ROLE

As Principal Cybersecurity Engineer, you will own security architecture and engineering end to end across PacBio's network, storage, high-performance computing (HPC), and cloud environments. You will design and implement controls, harden the systems we run, and ensure those controls stand up to auditors, customers, and attackers alike. You will serve as the technical lead for PacBio's ISO 27001 certification and for security-related SOX IT general controls, translating requirements into practical, well-evidenced controls that fit how our scientists, engineers, and operations teams work. This senior individual contributor role reports to the Head of Information Technology and sets the technical direction for cybersecurity at PacBio. This role requires comfort moving between hands‑on engineering, architecture, audit, and executive communication, and the ability to lead across IT, R&D, Software Engineering, Operations, and Finance without direct authority.

RESPONSIBILITIES

• Security architecture and roadmap: Define and own PacBio's security architecture, standards, and multi‑year engineering roadmap across enterprise, HPC, and cloud environments. Prioritize work based on risk and track progress with clear, measurable outcomes.
• ISO 27001 certification: Serve as technical lead for PacBio's ISO 27001 program. Help define ISMS scope, conduct risk assessments, implement and evidence Annex A controls, maintain the Statement of Applicability, and lead preparation for internal, certification, and surveillance audits.
• SOX IT general controls: Own security‑related ITGCs for financially significant systems, including logical access, privileged access, change management, and logging and monitoring. Partner with Finance, Internal Audit, and external auditors on control design, testing, evidence, and timely remediation of deficiencies.
• Network security: Own the security design of PacBio's networks, including segmentation, firewalls, secure remote and zero‑trust access, wireless, and DNS and email security.
• Storage, data protection, and resilience: Secure large‑scale research and enterprise storage through access controls, encryption, and data classification. Design and regularly test controls that allow PacBio to prevent, contain, and recover from disruptive cyberattacks, including immutable backups, recovery testing, and containment playbooks.
• HPC and cloud security: Secure the HPC clusters and cloud environments (AWS, Azure, and/or GCP) that support sequencing data analysis and R&D, including identity and privilege design, workload isolation, posture management, and security enforced through infrastructure as code.
• Device and server hardening: Define and enforce secure configuration baselines (e.g., CIS Benchmarks) for Windows, macOS, and Linux endpoints and servers, hypervisors, network devices, and IoT devices. Drive configuration compliance monitoring, vulnerability management, and patching with infrastructure and IT teams.
• Identity and access: Strengthen identity and access controls across the enterprise, including SSO, MFA, privileged access management, and periodic access reviews.
• Threat detection and response: Own EDR, SIEM, and MDR capabilities and the vendor relationships behind them. Tune detections for fidelity and coverage, lead response to significant security incidents, and run tabletop exercises and post‑incident reviews.
• Connected instruments and manufacturing: Partner with R&D, Product Security, and Operations to secure connected sequencing instruments, IoT devices, and manufacturing and lab networks without disrupting production.
• Automation: Automate security controls, audit evidence collection, and remediation using Python, Terraform, Ansible, or similar tools to make compliance continuous rather than periodic.
• Customer and vendor assurance: Lead technical responses to customer security questionnaires and reviews, and assess the security posture of key vendors and service providers.
• Technical leadership and communication: Mentor IT and engineering staff on secure practices, direct the work of security vendors and contractors, and clearly communicate risk, priorities, and progress to engineers, executives, and auditors.

QUALIFICATIONS

• Bachelor's degree in Computer Science, Information Security, Engineering, or a related field, or equivalent practical experience.
• 12 or more years of experience in cybersecurity engineering, security architecture, or infrastructure security, including 5 or more years as a senior technical lead or architect responsible for security across enterprise environments.
• Demonstrated experience as a technical lead for an ISO 27001 implementation, certification, or surveillance audit.
• Experience designing, operating, and evidencing SOX IT general controls in a public company.
• Deep, hands‑on expertise in network security architecture, including segmentation, next‑generation firewalls, VPN/ZTNA, and secure remote access.
• Proven experience securing enterprise and research storage, Linux‑based HPC environments, and at least one major cloud platform (AWS, Azure, or GCP).
• Hands‑on experience hardening servers, endpoints, network devices, and IoT devices using CIS Benchmarks or equivalent baselines, supported by configuration management and vulnerability management tools.
• Hands‑on experience with modern EDR platforms (e.g., CrowdStrike, SentinelOne, Microsoft Defender) and SIEM, including leading security incidents end to end.
• Proficiency in scripting and automation (Python, PowerShell, or Bash) and infrastructure as code (Terraform, Ansible).
• Working knowledge of security frameworks such as NIST CSF, NIST SP 800‑53, CIS Controls, and SOC 2.
• Excellent written and verbal communication skills, with a demonstrated ability to explain risk clearly and influence engineers, executives, and auditors without direct authority.

PREFERRED QUALIFICATIONS

• Experience with secure software development practices, including secure SDLC, threat modeling, and integrating SAST, SCA, secrets scanning, and container security into CI/CD pipelines.
• Experience in life sciences, genomics, biotech, medical devices, or another regulated industry, including protecting genomic or health data under HIPAA, GDPR, or CCPA/CPRA.
• Experience securing connected devices, embedded systems, or OT and manufacturing environments.
• Experience applying AI and LLM‑driven automation to security operations, with appropriate human oversight and guardrails.
• Certifications such as CISSP, CISM, CCSP, ISO 27001 Lead Implementer or Lead Auditor, GIAC, or a cloud security certification.
• Candidates must have current authorization to work in the United States without the need for present or future sponsorship.

WORK LOCATION & SCHEDULE

Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite. You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties. All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

Salary

#LI-Onsite Salary Range: $195,900.00 - $293,900.00

CORE VALUES

• BE CURIOUS. Our future depends on it.
• DELIGHT OUR CUSTOMERS. We strive to get it right every time.
• TAKE ACTION. We move fast and take calculated risks.
• EXECUTION MATTERS. Our customers rely on us.
• WORK TOGETHER. We care deeply about each other.

Equal Opportunity Employment

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.