Scientist, II

AbbVie; South San Francisco (CA); On-site; USD 140,000 - 190,000; Full time

Benefits offered by this job

Benefits package

Job summary

AbbVie’s CAR-T Biology team in South San Francisco is seeking a Scientist II to support in vivo CAR-T platform development from concept to preclinical stages. The role sits at the intersection of synthetic biology and immune modulation, requiring deep CAR-T biology expertise and strong collaboration with cross-functional teams.

You'll design CAR constructs, run advanced cell-based assays, analyze data, and communicate results through presentations and reports.

Qualifications

• BS, or equivalent education, with typically 7 or more years of experience; or MS, or equivalent education, with typically 5 or more years of experience, in immunology, cell and molecular biology, or related field.
• Demonstrated ability to independently design, perform, and interpret key experiments; quickly learn and apply new laboratory techniques; manage multiple tasks and meet deadlines; strong scientific writing and communication skills.
• Previous experience in chimeric antigen receptor (CAR) construct design, CAR-T production, and T cell function evaluation.
• Deep expertise in primary T cell isolation, activation, transduction, T cell cytotoxicity, proliferation, cytokine profiling, multi-color flow cytometry, and immunological assays (e.g., ELISA, Luminex).
• Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is a plus.

Responsibilities

• Design and execute in vitro assays to evaluate CAR-T biology, including cytotoxicity and T-cell function.
• Independently establish, track, and deliver on project milestones and timelines in line with program objectives.
• Organize, analyze, and present complex data; communicate strategies, results, and interpretations to stakeholders.
• Maintain comprehensive ELN records and documentation.

Skills

CAR-T biology

T-cell assays

T cell activation

Flow cytometry

Cytokine profiling

Scientific writing

Data communication

Education

BS or MS in immunology/cell/molecular biology

Tools

ELN

Liquid handling

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

Purpose: AbbVie’s CAR-T Biology team in South San Francisco, part of the Immuno-Oncology Organization, is seeking a Scientist II to support the development of in vivo CAR-T platforms from concept through preclinical development. You will work at the intersection of synthetic biology and immune modulation. The ideal candidate will bring deep expertise in CAR-T biology, T-cell functional assays, and therapeutic development. The role includes designing CAR constructs, executing advanced cell-based assays and collaborating with cross-functional teams to generate high-quality data that support pipeline programs.

• Design and execute in vitro assays to evaluate CAR-T biology, including assessment of cytotoxicity, T-cell effector function, and immune cell phenotyping.
• Independently establish, track, and deliver on project milestones and experimental timelines, ensuring alignment with program objectives and organizational priorities, while adapting to evolving scientific needs.
• Organize, analyze, and synthesize complex scientific data, and effectively communicate experimental strategies, results, and interpretations to internal and external stakeholders through clear and impactful presentations and scientific reports.
• Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).

Qualifications

• BS, or equivalent education, with typically 7 or more years of experience; or MS, or equivalent education, with typically 5 or more years of experience, in immunology, cell and molecular biology, or related field.
• Demonstrated ability to independently design, perform, and interpret key experiments to address scientific questions. Proven capacity to quickly learn and apply new laboratory techniques. Able to manage multiple tasks efficiently while meeting deadlines. Strong skills in scientific writing and verbal communication.
• Previous experience in chimeric antigen receptor (CAR) construct design, CAR-T production, and T cell function evaluation.
• Deep expertise in primary T cell isolation, activation, transduction, T cell cytotoxicity, proliferation, cytokine profiling, multi-color flow cytometry, and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required.
• Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is a plus.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this roleat the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on manyfactors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount isearned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that areallocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolutediscretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html