Scientist, II

BioSpace; South San Francisco (CA); On-site; USD 140,000 - 190,000; Full time

Job summary

AbbVie in South San Francisco is seeking a Scientist II to advance in vivo CAR-T platforms from concept to preclinical development. You will design CAR constructs, perform advanced cell-based assays and generate high-quality data that support pipeline programs.

The ideal candidate brings deep CAR-T biology experience and strong T-cell functional assay skills, with proven ability to communicate findings through presentations and reports within a collaborative Immuno-Oncology environment.

Qualifications

• BS or MS in immunology, cell biology, or related field with 5+ years experience (or equivalent).
• Ability to independently design, perform, and interpret experiments; strong scientific writing and communication.
• Experience in CAR design, CAR-T production, and T cell function evaluation.
• Deep expertise in primary T cell isolation, activation, transduction, cytotoxicity, proliferation, cytokine profiling, and multi-color flow cytometry.
• Experience with in vitro assay development and semi-automated liquid handling for high-throughput workflows is a plus.

Responsibilities

• Design and execute in vitro CAR-T assays to evaluate cytotoxicity and T-cell function.
• Track and deliver project milestones with evolving scientific needs.
• Analyze and present complex data to stakeholders through reports and presentations.
• Maintain detailed ELN records.

Skills

CAR-T biology

T-cell functional assays

data analysis

scientific writing

flow cytometry

Education

BS or MS in immunology / cell biology

PhD preferred

Tools

ELN

Luminex

Flow Cytometry

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Purpose

Job Description

AbbVies CAR-T Biology team in South San Francisco, part of the Immuno-Oncology Organization, is seeking a Scientist II to support the development of in vivo CAR-T platforms from concept through preclinical development. You will work at the intersection of synthetic biology and immune modulation. The ideal candidate will bring deep expertise in CAR-T biology, T-cell functional assays, and therapeutic development. The role includes designing CAR constructs, executing advanced cell-based assays and collaborating with cross-functional teams to generate high-quality data that support pipeline programs.

Key Responsibilities

• Design and execute in vitro assays to evaluate CAR-T biology, including assessment of cytotoxicity, T-cell effector function, and immune cell phenotyping.
• Independently establish, track, and deliver on project milestones and experimental timelines, ensuring alignment with program objectives and organizational priorities, while adapting to evolving scientific needs.
• Organize, analyze, and synthesize complex scientific data, and effectively communicate experimental strategies, results, and interpretations to internal and external stakeholders through clear and impactful presentations and scientific reports.
• Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).

Qualifications

• BS, or equivalent education, with typically 7 or more years of experience; or MS, or equivalent education, with typically 5 or more years of experience, in immunology, cell and molecular biology, or related field.
• Demonstrated ability to independently design, perform, and interpret key experiments to address scientific questions. Proven capacity to quickly learn and apply new laboratory techniques. Able to manage multiple tasks efficiently while meeting deadlines. Strong skills in scientific writing and verbal communication.
• Previous experience in chimeric antigen receptor (CAR) construct design, CAR-T production, and T cell function evaluation.
• Deep expertise in primary T cell isolation, activation, transduction, T cell cytotoxicity, proliferation, cytokine profiling, multi-color flow cytometry, and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required.
• Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is a plus.

Additional Information

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employer remains in the Company’s sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html