Scientist, II

Initial Therapeutics, Inc.; Massachusetts; On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Benefits package

Short-term incentive programs

Job summary

AbbVie is seeking a highly motivated pharmacologist to advance inflammatory GI disorders through in vivo and in vitro studies. This role focuses on test article screening, assay development, and building biology packages for early stage programs.

The candidate will design, execute, and present results, contributing significantly to our GI/Immunology Discovery Research group. Strong communication skills and hands-on experimental leadership are essential.

Qualifications

• Demonstrated ability to lead wet-lab experiments.
• Experience with handling human tissue in research settings.
• Proficient in primary cell culture and inflammatory stimulation.
• Experience with colitis models or humanized mouse models.
• Strong scientific writing and presentation skills.

Responsibilities

• Autonomous laboratory research and method development, requiring minimal direction.
• Execute discovery screening funnels for novel test articles.
• Design, execute and analyze in vivo pharmacology studies in colitis or GI mouse models.
• Prepare and execute experiments with human blood or intestinal tissue.
• Primary author of regulatory documents.
• Understand and adhere to corporate safety and regulatory standards.

Skills

In vivo pharmacology

In vitro pharmacology

Mouse models

Cell culture

Data analysis

Scientific communication

Education

Bachelor's degree or equivalent

Master's degree preferred

Tools

RT-qPCR

Western blot

Flow cytometry

Multi-parameter flow cytometry

Job description

Company Description

Job Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

AbbViesGastrointestinal(GI)/Immunology Discovery Research group is looking for a highly motivated andexperienced invivo and in vitropharmacologistto play an integral role inadvancing therapeutics to treat inflammatory GI disorders.This position offers an exciting opportunity tounderstand thepharmacodynamic effectsof experimental medicineswith GI relevant in vitro and in vivo assays.

The ideal candidate would work within the highly matrixed and collaborativeDiscovery Immunologyteam toguidetest articlescreening and assay development as well asbuild biology packages forearly stageprograms.Experimental focus will be ondeveloping andleveragingin vivo and in vitro systems tohelpunderstand the impact of test articlesin mucosal immunity.The candidate is expected to design, execute,interpretand present innovative research to advance programstowards the clinic.We are seeking a hands-on experimentalist who isproficientwithin vivo and in vitrocell biology research andhasdemonstratedscientificleadership withinternal and externalstake holders/experts.The expectation is that the candidate would dedicatethe majority oftheir time toward wet laboratory experimentation, dataanalysisand presentation.In addition, we are seeking a candidatewith excellent written and oral communication skills.The candidate will have the opportunity to present their results at team and internal/external science meetings.Priortechnicalexperience inIBDmouse models, humanized mice,biologicsmolecule screening, and handling of human tissuearerequired.

Major Responsibilities:

• Highly autonomous and productive in performing laboratory research and method development, requiring only minimal direction from supervisor
• Execute ondiscovery screening funnels fornovel test articles
• Design, execute and analyze in vivopharmacologystudies in colitis or other GI mouse models
• Prepareand execute experiments withhuman blood or intestinal tissue
• Formulate conclusions and design follow-on experiments based on multidisciplinary data
• Primary author of regulatory documents.
• Understand and adhere to corporate standardsregardingcode of conduct, safety,appropriate handlingof materials, controlled drug and radioactive compounds, and animal care

Qualifications

• Bachelors Degree or equivalent education and typically,7years ofworkexperience,Masters Degreeor equivalent education and typically5years of work experience
• Experiencewithin vitro and in vivocell killingendpoints preferred
• Highly proficient in primary cell culture, including isolation of human and rodent cells and activation with inflammatory stimulationis preferred
• Experience with ex vivo intestinal tissue assays
• Possess thorough theoretical and practical understanding ofownscientific discipline, especially within gastrointestinal physiology and inflammation.
• Highly proficientand efficientwithin vivo techniques such as mouse restraint, PO, ROand IP dosing routes, and rodent necropsy.Experience with some colitis modelsor humanize mouse modelsisrequired.
• Technical capabilities including RT-qPCR,Westernblot,multi-parameterflowcytometry
• Demonstrated ability to learn,understandand master new experimental techniques.
• Demonstrated scientific writing skills and strong verbal communication skillsthrough publication and conference presentations.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographiclocation, and we may ultimately pay more or less than the posted range. This range may bemodified in thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to be wages or compensation until such amount is earned, vested, and determinable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or anyother form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssole andabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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