Scientist I, Quality Control (2nd Shift)

Scorpion Therapeutics; Madison (WI); On-site; USD 90,000 - 108,000; Full time

Job summary

Scorpion Therapeutics in Madison, WI seeks a Scientist I, Quality Control on 2nd shift to support analytical method validation, transfer, and routine QC testing across drug substance, product, and stability studies.

Responsibilities include executing validated analytical methods, operating LC-MS and chromatographic systems, interpreting data, and ensuring regulatory compliance through thorough documentation and collaborative problem solving.

Qualifications

• BS in Chemistry with 5+ years lab experience or MS with 3+ years.
• Experience with cGMP and ICH lab operations and documentation.
• Hands-on testing of oligonucleotides, peptides, or synthetic biomolecules.
• Strong data integrity and attention to detail; adherence to turnaround targets.

Responsibilities

• Perform analytical testing of materials and products using validated methods.
• Execute method validation, method transfer, and routine QC testing per guidelines.
• Operate and troubleshoot LC-MS, HPLC/UHPLC, GC, KF, FTIR, LAL, and Raman systems.
• Analyze data and stability trends; investigate results and ensure quality.
• Collaborate cross-functionally and mentor colleagues; document per cGMP.

Skills

Method validation

Method transfer

QC testing

cGMP compliance

Documentation

Data interpretation

Troubleshooting

Mentoring

Education

BS in Chemistry

MS in Chemistry

Tools

LC-MS

HPLC/UHPLC RP

AEX-HPLC

GC

Karl Fischer titration

Endotoxin/LAL

Raman spectroscopy

Job description

The Position: Scientist I, Quality Control (2nd shift; eligible for a 10% shift differential).

Support analytical method validation, method transfer, and quality control testing for pharmaceutical raw materials, in-process manufacturing samples, drug substance, drug product, and stability studies.

Responsibilities:

• Perform analytical testing of raw materials, in-process samples, drug substances, drug products, and stability samples using validated methods.
• Execute method validation, method transfer, and routine QC testing per cGMP and ICH guidelines.
• Operate, troubleshoot, and interpret data from analytical instrumentation (LC-MS; HPLC/UHPLC—RP and AEX; GC; Karl Fischer titration; FTIR; Endotoxin/LAL; Raman spectroscopy).
• Analyze/interpret data, including stability trends and degradation profiles.
• Independently investigate analytical results; make sound scientific decisions ensuring data quality and compliance.
• Collaborate cross-functionally with Analytical Development, Manufacturing, and Quality.
• Lead technical discussions, troubleshoot analytical challenges, and contribute to continuous improvement.
• Train/mentor colleagues; maintain cGMP/GDP-compliant documentation.
• Support lab investigations, method improvements, and other QC initiatives.

Requirements:

• BS in Chemistry (or related) with 5+ years lab experience, or MS with 3+ years.
• cGMP and ICH laboratory requirements/operations knowledge.
• Strong documentation and attention to detail; able to work within hold times/turnaround targets.
• Experience testing oligonucleotides, peptides, or synthetic biomolecules.
• Hands-on experience with LCMS, AEX-HPLC, RP-HPLC/UHPLC, Karl Fischer titration, or LAL/endotoxin testing.
• Experience supporting in-process (real-time) testing in a manufacturing-adjacent QC lab.
• Proficient in analytical instrumentation, test methodology/validations/transfers, data acquisition systems, and cGMP policies/practices.

Pay range: $90,000 USD - $108,000 USD.