Associate Scientist III, Quality Control (2nd shift)

Scorpion Therapeutics; Madison (WI); On-site; USD 80,000 - 100,000; Full time

Job summary

Scorpion Therapeutics is seeking an IPC/QC professional to support in-process control testing for defined IPC lanes using LCMS, HPLC, UV, LAL, and Karl Fischer methods. The role requires strong GDP discipline and cGMP knowledge, with hands-on in a GMP lab.

The candidate will handle data recording, support investigations, and communicate during shift handoffs to ensure uninterrupted batch progression and accurate results.

Qualifications

• must have GDP knowledge and strong attention to detail
• familiar with cGMP and ICH requirements
• proficient with analytical instrumentation and test method validation/transfers
• able to work with real-time in-process testing data

Responsibilities

• Perform IPC sample receipt, preparation, and testing per approved methods/SOPs for defined IPC lanes
• Execute LCMS, AEX and RP-HPLC purity/identity; UV, Karl Fischer, pH, and LAL testing
• Record raw data in real time per GDP and ensure data integrity
• Support investigations (OOS/OOT/deviations) with data review and re-test work
• Monitor hold times and communicate risks impacting batch progression
• Maintain a clean GMP-compliant lab bench and 5S organization
• Communicate effectively during shift handoff for continuity of testing and batch status

Job description

Responsibilities

• Perform in-process control (IPC) sample receipt, preparation, and testing per approved methods/SOPs for defined IPC sample lanes (e.g., crude pool, post-purification pool, post-UF/DF intermediate, final strand/duplex release).
• Execute analytical techniques including LCMS, AEX and RP-HPLC purity/identity testing, UV (A260) concentration/assay, Karl Fischer water content, pH, and bacterial endotoxin (LAL) testing.
• Record raw data, calculations, and results in real time in compliance with good documentation practices (GDP).
• Support investigations (OOS, OOT, deviations) by providing accurate data, reviewing raw data trends, and performing confirmatory/re-test work.
• Monitor sample hold times; promptly communicate any hold-time risk, atypical result, or equipment issue impacting batch progression.
• Maintain a clean, organized, GMP-compliant lab bench/work area (including 5S).
• Communicate effectively during shift handoff to ensure continuity of testing and batch status.

Requirements

• MS in Chemistry (or related) with 2+ years’ relevant regulated laboratory experience, or BS in Chemistry (or related) with 5+ years in a GMP QC/analytical laboratory.
• Strong attention to detail and GDP; ability to work against hold times/turnaround targets.
• Prior experience testing oligonucleotides/peptides/synthetic biomolecules.
• Hands-on experience with LCMS, AEX-HPLC, RP-HPLC/UHPLC, Karl Fischer titration, and/or LAL/endotoxin testing.
• Experience with in-process (real-time) testing in a manufacturing-adjacent QC lab.
• Knowledge of cGMP and ICH laboratory requirements; proficiency with analytical instrumentation and test method validation/transfers.

Shift: 2nd shift, 1 pm–11:30 pm (Mon–Thu); includes 10% shift differential.

Pay: $80,000–$100,000 (Wisconsin pay range).

Application: Candidates must have current, valid authorization to work in the country where the role is located.