Scientist I, Oncology Drug Discovery & Protein Therapeutics

Generate Biomedicines; Somerville (MA); On-site; USD 90,000 - 120,000; Full time

Job summary

Generate:Biomedicines is seeking a Scientist I with expertise in cancer biology to support discovery and development of protein-based oncology therapeutics. This highly laboratory-focused role will plan and execute cellular assays, interpret results, and generate reproducible data to inform project decisions.

As part of a multidisciplinary team, you will establish cell lines, perform genetic editing, and collaborate across functions while maintaining rigorous documentation and staying current

Qualifications

• PhD in cancer biology, cell biology, immunology, immuno-oncology, or related field with 0–2 years experience; or Master's with six years experience; or Bachelor's with eight years experience; or eleven years experience.
• Strong foundation in cancer biology and hands-on mammalian cell culture expertise.
• Hands-on experience with in vivo tumor models (xenograft, PDX, or syngeneic) including tumor growth and biomarker assessment.
• Experience with cell line engineering and standard molecular biology/biochemistry techniques (cloning, PCR/RT-qPCR, Western blot).
• Experience developing and troubleshooting quantitative cell-based assays (cytotoxicity, viability, internalization).
• Proficiency in flow cytometry and measuring proteins/cytokines with ELISA/AlphaLISA/MSD.
• Ability to independently plan experiments, use proper controls, analyze quantitative data, and recommend follow-up studies.
• Experience communicating findings and collaborating in a multidisciplinary project team.

Responsibilities

• Establish, maintain, and characterize cancer cell lines, tumor organoids, and primary cells to support target validation and therapeutic evaluation.
• Generate and validate engineered cell lines using transfection, transduction, and CRISPR-based editing to modulate target expression or reporters.
• Design, execute, and troubleshoot assays of cell viability, proliferation, cytotoxicity, target binding, and receptor/antibody internalization.
• Apply flow cytometry, live-cell imaging, plate-based assays, and immunoassays (ELISA, AlphaLISA, MSD) to characterize therapeutic activity and mechanism.
• Analyze, interpret, and present experimental findings, recommending next steps for project decisions.
• Collaborate with Automation, Computational Sciences, Protein Sciences, and high-throughput screening to advance goals.
• Maintain complete and accurate experimental records and stay current with oncology/biologics advances.

Skills

Cancer biology

Mammalian cell culture

Flow cytometry

Assay development

Data analysis

Scientific communication

Education

PhD in cancer biology or related field

Master's with 6 years experience

Bachelor's with 8+ years experience

Tools

CRISPR editing

Transfection

Western blotting

PCR/RT-qPCR

ELISA/AlphaLISA/MSD

Job description

Generate:Biomedicines is seeking a Scientist I with expertise in cancer biology to support discovery and development of protein-based oncology therapeutics. This highly laboratory-focused role will plan and execute cellular assays, interpret results, and generate reproducible data to inform project decisions.

As part of a multidisciplinary team, you will establish cell lines, perform genetic editing, and collaborate across functions while maintaining rigorous documentation and staying current