Scientist I/II

Spectraforce Technologies, Inc.; South San Francisco (CA); On-site; USD 70,000 - 95,000; Full time

Job summary

Spectraforce Technologies, Inc. seeks a Scientist I/II in South San Francisco to support the Investigative Toxicology group within Translational Safety.

The role focuses on cell culture of primary cells and lines for in vitro screenings, with assays measuring cytotoxicity and metabolic changes, and contributing to scientific publications. Applicants should have a BS/BA in life sciences and 1–3+ years of lab experience, with strong data analysis and ability to present results.

Qualifications

• BS/BA in life sciences required; MS desirable.
• 1–3+ years of laboratory experience with hypothesis-driven research.
• Experience with cell culture, cytometry, or related assays is highly desired.

Responsibilities

• Culture and expand primary cells and cell lines for in vitro screenings.
• Perform cytotoxicity and metabolic assays, capture images, and analyze data.
• Provide scientific support for assays and contribute to reports and SOPs.

Skills

Cell culture

Data analysis

Scientific writing

Education

BS/BA in life sciences

Tools

Luminex/ELISAs

Flow cytometry

High content screening

Confocal microscopy

Gene expression analysis

Job description

Position Title: Scientist I/II

Work Location: 1 DNA Way, South San Francisco, CA, 94080

Assignment Duration: 12 Months

Work Arrangement: Onsite

Position Summary

This position is in the Investigative Toxicology Group within the department of Translational Safety in The Organization's Research and Early Development organization. The mission of the Investigative Toxicology group is to elucidate the mechanisms underlying toxicities that are observed non-clinically and/or in clinical trials through hypothesis driven research.

Background & Context

This process involves closely collaborating with scientists across the organization to support the overall safety assessment for our novel therapeutics spanning drug discovery through clinical development and marketing. The group provides fit-for-purpose wet lab-based investigation to address target safety assessment, lead optimization, and issue mitigation by employing state-of-the-science in vitro and ex vivo approaches. As such, we are constantly establishing new platforms and technologies to support a constantly changing portfolio, novel modalities, and emerging therapeutic area needs. We are looking for a highly motivated candidate to work in collaboration with other researchers in the Investigative Toxicology lab.

Key Responsibilities

• This individual must have experience in cell culture and will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings and performing assays which may include assessments of cytotoxicity and metabolic changes of cells, capturing cell culture images using high content imaging, flow cytometry, and other technologies.
• This individual will be working with cells from a broad range of tissues (immune cells, blood, liver, vascular, ocular, immortalized cell lines) and is expected to make detailed observations related to experiments, perform, analyze data, and interpret results.
• This individual will contribute scientific insights and work in projects related to peer review publications.
• Candidate will provide scientific and technical support to assays and platforms supported by the Investigative Toxicology group by:
  1. Performing experiments involving: immortalized and primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry. Experience with these methodologies is desirable, but not required.
  2. Maintaining documentation related to protocol execution and results.
  3. Writing protocols and contributing to final reports as appropriate.
  4. Adhering to departmental SOPs to ensure study integrity and quality.
  5. Conducting experiments with a high level of independence and initiative.
  6. Performing tasks with minimal direct supervision for routine methods and studies commonly employed by the team.

Qualification & Experience

• Bachelors (BS/BA) in pharmacology, pharmaceutical science, biology, bioengineering, chemistry, physiology, or related discipline is required; Masters (MS) degree is desirable, but not required.
• 1-3+ years of laboratory experience with hypothesis-driven research.
• Ability to analyze, integrate, and present data in a presentation is required.
• Experience with immortalized and/or primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry is highly desired.
• Experience with complex in-vitro model systems is highly desired.

Working Conditions & Physical Demands (If Applicable)

• Sitting or standing for extended periods.
• Performing repetitive tasks such as cell culture, pipetting and labeling tubes.
• Collaboration across the Investigative Toxicology team and with key stakeholders.
• Work with potentially hazardous materials including (but not limited to): chemotherapeutics, biological hazards, and human primary cells.