Scientist I, High-Throughput Biology

Eikon Therapeutics; Millbrae (CA); On-site; USD 123,000 - 149,000; Full time

Benefits offered by this job

401k with company match

Medical, dental, and vision insurance

Mental health benefits

Paid time off and holidays

Life/AD&D insurance

Parental leave

Lunch program on-site

Job summary

Eikon Therapeutics is hiring for a biology-focused scientist to pioneer live-cell, high-throughput assays using proprietary super-resolution microscopy. You will design, run, and optimize scalable assays, collaborating with computational biologists and software engineers to apply advanced analytics and machine learning to large datasets.

The role emphasizes delivering reproducible data, strong technical skills in mammalian cell culture, microscopy, and statistics, and helping train junior

Qualifications

• Ph.D. or Master’s plus 10 years of relevant experience in Biology, Bioengineering, Biotechnology, or related field.
• Proficiency in mammalian cell culture with sterile technique.
• Proficiency in laboratory techniques and equipment relevant to molecular and cellular biological research.
• Demonstrated experience in systematic optimization and validation of biological assays.
• Strong analytical and troubleshooting skills with novel assay technologies.
• Working experience in quantitative fluorescence microscopy and/or super-resolution microscopy.
• Working experience with relevant quantitative and/or statistical analysis using common software tools (e.g., Microsoft Suite, GraphPad Prism, etc.).
• Working experience with one or more high-level programming languages (e.g., Python, MATLAB or R) to perform large dataset analysis and visualization.
• Excellent communication skills, with the ability to convey scientific concepts effectively.
• Collaborative mindset with the capacity to work effectively within multidisciplinary teams.
• Proactive and adaptable to evolving research priorities and challenges.
• Working experience in protein dynamics using single-molecule microscopy is preferred.
• Working experience with high-throughput instrumentation and automation systems is preferred.

Responsibilities

• Design, execute, and analyze robust and reproducible experiments to optimize, validate, and scale up live-cell imaging-based assays for high-throughput screening using Eikon’s proprietary super-resolution microscopy platform.
• Collaborate with computational biologists and software engineers to apply state-of-the-art computational and statistical methods including machine-learning to analyze large datasets.
• Summarize and deliver timely, high-quality and actionable data to drive project team decisions across drug discovery portfolios.
• Exercise good scientific judgment and provide data-driven recommendations to project teams.
• Maintain organized and comprehensive electronic records of experiments, results, and protocols in adherence to company standards and regulatory requirements.
• Work closely with the High-Throughput Biology Operations Team to transfer optimized processes into productionized operations workflows with well-documented standard operating procedures.
• Collaborate and communicate across a diverse team of biologists, chemists, and engineers.
• Contribute to the growth and training of junior scientists.

Skills

Mammalian cell culture

Laboratory techniques

Biological assay optimization

Data analysis

Microscopy (fluorescence & SRM)

Programming (Python/MATLAB/R)

Communication skills

Collaboration

Adaptability

Single-molecule microscopy experience

Automation systems familiarity

Education

Ph.D. or MS + 10 years experience in Biology/Bioengineering

Bachelor’s degree + 12 years experience in related field

Tools

Microsoft Office

GraphPad Prism

Job description

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.

Position

As a member of the High-Throughput Biology Team, you will play a key role in pioneering drug discovery screening assays using Eikon’s proprietary live-cell, single-molecule high-throughput super-resolution microscopy platform. You will work at the intersection of biology, automation engineering, and computational science to design, execute and deliver scalable, reproducible, decision-enabling biological data that drives progress across drug discovery portfolios.

About You

You are a highly motivated, rigorous, and interdisciplinary scientist who enjoys developing, optimizing, and validating live-cell imaging-based assays at scale to push the frontier of drug discovery. You are creative, data-driven, and skilled at problem solving in a fast-paced, dynamic, and matrixed environment. You are conscientious, detail-oriented, and organized, and are committed to delivering high-quality and actionable data in a timely manner. You are an effective communicator and teammate who is eager to learn and collaborate with people from diverse scientific backgrounds.

What You’ll Do

• Design, execute, and analyze robust and reproducible experiments to optimize, validate, and scale up live-cell imaging-based assays for high-throughput screening using Eikon’s proprietary super-resolution microscopy platform.
• Collaborate with computational biologists and software engineers to apply state-of-the-art computational and statistical methods including machine-learning to analyze large datasets.
• Summarize and deliver timely, high-quality and actionable data to drive project team decisions across drug discovery portfolios.
• Exercise good scientific judgment and provide data-driven recommendations to project teams.
• Maintain organized and comprehensive electronic records of experiments, results, and protocols in adherence to company standards and regulatory requirements.
• Work closely with the High-Throughput Biology Operations Team to transfer optimized processes into productionized operations workflows with well-documented standard operating procedures.
• Collaborate and communicate across a diverse team of biologists, chemists, and engineers.
• Contribute to the growth and training of junior scientists.

Qualifications

• Ph.D. or Master’s plus 10 years of relevant experience or Bachelor’s degree plus 12 years of relevant experience in Biology, Bioengineering, Biotechnology, or related field.
• Proficiency in mammalian cell culture with sterile technique.
• Proficiency in laboratory techniques and equipment relevant to molecular and cellular biological research.
• Demonstrated experience in systematic optimization and validation of biological assays.
• Strong analytical and troubleshooting skills with novel assay technologies.
• Working experience in quantitative fluorescence microscopy and/or super-resolution microscopy.
• Working experience with relevant quantitative and/or statistical analysis using common software tools (e.g., Microsoft Suite, GraphPad Prism, etc.).
• Working experience with one or more high-level programming languages (e.g., Python, MATLAB or R) to perform large dataset analysis and visualization.
• Excellent communication skills, with the ability to convey scientific concepts effectively.
• Collaborative mindset with the capacity to work effectively within multidisciplinary teams.
• Proactive and adaptable to evolving research priorities and challenges.
• Working experience in protein dynamics using single-molecule microscopy is preferred.
• Working experience with high-throughput instrumentation and automation systems is preferred.

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:

• 401k plan with company matching
• Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
• Mental health and wellness benefits
• Weeklong summer and winter holiday shutdowns
• Generous paid time off and holiday policies
• Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
• Enhanced parental leave benefit
• Daily subsidized lunch program when on-site

The expected salary range for this role is $123,000 to $149,100 depending on skills, competency, and the market demand for your expertise.

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

We are currently not accepting any new third-party agencies or firms at this time. Please do not forward unsolicited agency resumes to our website, employees or Human Resources. Eikon Therapeutics will not pay fees to any third-party agency or firm associated with unsolicited resumes.

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As set forth in Eikon Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

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A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

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