Scientist I, High-Throughput Biology

Eikon Therapeutics, Inc.; Millbrae (CA); Sur place; USD 123 000 - 149 000; Plein temps

Avantages offerts par ce poste

401k matching

Medical insurance (Eikon pays most)

Dental insurance

Vision insurance

Mental health and wellness benefits

Paid time off and holidays

Life/AD&D Insurance

Parental leave

Lunch program on-site

Résumé du poste

Eikon Therapeutics, Inc. is seeking a scientifically rigorous, interdisciplinary professional to advance live-cell imaging-based assays for high-throughput drug discovery.

You will work at the interface of biology, automation engineering, and computation, delivering scalable, reproducible data to support portfolio decisions. You will collaborate with computational biologists and software engineers to apply advanced ML and statistical methods, ensuring timely, high-quality results and robust

Qualifications

• PhD or MS/BS with 10+ years (or 12+ years with BS) in Biology, Bioengineering, Biotechnology, or related field.
• Proficiency in mammalian cell culture with sterile technique.
• Experience with live-cell or high-throughput biological assays.
• Strong data analysis and troubleshooting skills.

Responsabilités

• Design, execute, and analyze robust live-cell imaging-based assays for high-throughput screening.
• Collaborate with computational biologists and software engineers to apply ML and statistics to large datasets.
• Summarize and deliver high-quality data to drive decisions across drug discovery portfolios.
• Maintain organized records per company standards and regulatory requirements.
• Transfer optimized processes into productionized workflows with documented SOPs.
• Collaborate across biologists, chemists, and engineers; contribute to training junior scientists.

Connaissances

Mammalian cell culture

Live-cell imaging

Data analysis

Computational thinking

Problem solving

Communication

Team collaboration

Formation

PhD or MS/BS with extensive experience

Outils

Python

MATLAB

R

GraphPad Prism

Microsoft Excel

Description du poste

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.

Position

As a member of the High-Throughput Biology Team, you will play a key role in pioneering drug discovery screening assays using Eikon’s proprietary live-cell, single-molecule high-throughput super-resolution microscopy platform. You will work at the intersection of biology, automation engineering, and computational science to design, execute and deliver scalable, reproducible, decision-enabling biological data that drives progress across drug discovery portfolios.

About You

You are a highly motivated, rigorous, and interdisciplinary scientist who enjoys developing, optimizing, and validating live-cell imaging-based assays at scale to push the frontier of drug discovery. You are creative, data-driven, and skilled at problem solving in a fast-paced, dynamic, and matrixed environment. You are conscientious, detail-oriented, and organized, and are committed to delivering high-quality and actionable data in a timely manner. You are an effective communicator and teammate who is eager to learn and collaborate with people from diverse scientific backgrounds.

What You’ll Do

• Design, execute, and analyze robust and reproducible experiments to optimize, validate, and scale up live-cell imaging-based assays for high-throughput screening using Eikon’s proprietary super-resolution microscopy platform.
• Collaborate with computational biologists and software engineers to apply state-of-the-art computational and statistical methods including machine-learning to analyze large datasets.
• Summarize and deliver timely, high-quality and actionable data to drive project team decisions across drug discovery portfolios.
• Exercise good scientific judgment and provide data-driven recommendations to project teams.
• Maintain organized and comprehensive electronic records of experiments, results, and protocols in adherence to company standards and regulatory requirements.
• Work closely with the High-Throughput Biology Operations Team to transfer optimized processes into productionized operations workflows with well-documented standard operating procedures.
• Collaborate and communicate across a diverse team of biologists, chemists, and engineers.
• Contribute to the growth and training of junior scientists.

Qualifications

• Ph.D. or Master’s plus 10 years of relevant experience or Bachelor’s degree plus 12 years of relevant experience in Biology, Bioengineering, Biotechnology, or related field.
• Proficiency in mammalian cell culture with sterile technique.
• Proficiency in laboratory techniques and equipment relevant to molecular and cellular biological research.
• Demonstrated experience in systematic optimization and validation of biological assays.
• Strong analytical and troubleshooting skills with novel assay technologies.
• Working experience in quantitative fluorescence microscopy and/or super-resolution microscopy.
• Working experience with relevant quantitative and/or statistical analysis using common software tools (e.g., Microsoft Suite, GraphPad Prism, etc.).
• Working experience with one or more high-level programming languages (e.g., Python, MATLAB or R) to perform large dataset analysis and visualization.
• Excellent communication skills, with the ability to convey scientific concepts effectively.
• Collaborative mindset with the capacity to work effectively within multidisciplinary teams.
• Proactive and adaptable to evolving research priorities and challenges.
• Working experience in protein dynamics using single-molecule microscopy is preferred.
• Working experience with high-throughput instrumentation and automation systems is preferred.

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:

• 401k plan with company matching
• Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
• Mental health and wellness benefits
• Weeklong summer and winter holiday shutdowns
• Generous paid time off and holiday policies
• Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
• Enhanced parental leave benefit
• Daily subsidized lunch program when on-site

The expected salary range for this role is $123,000 to $149,100 depending on skills, competency, and the market demand for your expertise.
Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.