Scientist I, DMPK

Revolution Medicines, Inc.; San Francisco (CA); On-site; USD 119,000 - 149,000; Full time

Job summary

Revolution Medicines, Inc. is seeking a DMPK scientist to design and execute in vitro and in vivo metabolism studies, profile metabolites, and support candidate selection and safety strategies.

You will work closely with Discovery, Pharmacology, and Regulatory teams to advance oncology programs. Qualifications include a PhD in Pharmaceutical Sciences, Chemistry, or Biochemistry, hands-on mass spectrometry metabolite profiling, PK/ADME knowledge, and experience with PK software such as WinNonlin.

Qualifications

• PhD in Pharmaceutical Sciences, Chemistry or Biochemistry with >2 years post‑grad experience.
• Hands-on metabolite profiling using high resolution mass spectrometry.
• Solid understanding of drug metabolism, PK, ADME principles.
• Experience using PK software such as WinNonlin.
• Excellent verbal and written communication, problem‑solving and critical thinking.
• Ability to independently design experiments, analyze data and report results.
• Oncology drug discovery experience is a plus.
• PBPK modeling and DDI risk assessment are preferred.

Responsibilities

• Design and execute in vitro and in vivo metabolite identification studies.
• Characterize major metabolites to support candidate selection and safety strategies.
• Perform mechanistic studies on metabolic pathways and enzyme kinetics.
• Author and review DMPK sections of regulatory submissions.
• Collaborate with Discovery, Clinical Pharmacology, Medicinal Chemistry, and Toxicology teams.

Skills

PhD in Pharmaceutical Sciences / Chem/

Metabolite profiling with high-res MS

Drug metabolism, PK, ADME principles

PK software (WinNonlin)

Strong communication and problem‑solv.

Independently design experiments

Oncology drug discovery experience (p

PBPK modeling and DDI risk assessment

Education

PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field

Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor - all in service of patients.

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

• Design and execute in vitro and in vivo metabolite identification studies using liver microsomes, hepatocytes, recombinant enzymes, and biological samples (blood, plasma, tissue, urine, bile, etc.), and perform metabolite profiling and structural elucidation.
• Characterize major, unique, or disproportionate metabolites to support candidate selection, MIST (Metabolites in Safety Testing) analysis, and metabolite regulatory strategy.
• Design and perform mechanistic studies to understand metabolic pathways and enzyme kinetics; work with pharmaceutical product teams to characterize drug degradation products and impurities.
• Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies.
• Build and maintain strong collaborative partnerships across functional areas, e.g., Discovery research, Clinical Pharmacology, Medicinal Chemistry, Pharmaceutical Development, Toxicology, and Translational Research.

Required Skills, Experience and Education:

• A highly motivated individual with a PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field, with >2 years of experience after graduation.
• Demonstrated hands-on experience in metabolite profiling using high resolution mass spectrometry.
• Solid understanding of drug metabolism, pharmacokinetics, and ADME principles.
• Demonstrated hands-on experience in using PK software (e.g. WinNonlin).
• Excellent verbal and written communication, problem-solving and critical thinking skills.
• Ability to independently design experiments, analyze data, and communicate results.

Preferred Skills:

• Prior experience with oncology drug discovery is preferred.
• Previous experience with PBPK modeling and DDI risk assessment is preferred.
• Effective communication and documentation skills.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Base Pay Salary Range

$119,000 - $149,000 USD