Scientist I: Computational Drug Discovery

The Henry M. Jackson Foundation for the Advancement of Military Medicine; Silver Spring (MD); On-site; USD 78,000 - 100,000; Full time

Job summary

The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) invites applications for a Scientist I to support multidisciplinary infectious-disease drug discovery at WRAIR in Silver Spring, MD.

The role integrates computational drug discovery, structural biology, and experimental biology to identify and optimize therapeutic candidates. The successful candidate will design and apply structure-based and ligand-based approaches, collaborate across biology, chemistry, and

Qualifications

• Doctorate degree in computational biology, computational chemistry, structural biology, biochemistry, molecular biology, parasitology, pharmaceutical sciences, bioinformatics, or related field.
• Minimum 2–5 years of experience in infectious-disease drug discovery and computational methods.
• Experience with docking, dynamics, virtual screening, and structure-based drug design.
• Ability to integrate computational predictions with experimental data.
• Strong scientific productivity demonstrated through publications or presentations.

Responsibilities

• Design and execute computational drug-discovery workflows using structure-based and ligand-based approaches.
• Apply physics-based, machine-learning, and other computational methods to target characterization and hit prioritization.
• Perform structural modeling and analysis of proteins and complexes to identify binding sites and interactions.
• Conduct computational screening to support identification and optimization of candidates.
• Apply free-energy and related methods to characterize binding and guide optimization.
• Collaborate with laboratory scientists to design validation studies and translate findings.
• Analyze data, develop reproducible workflows, and report results to the team.
• Contribute to studies of pathogen targets and host–pathogen interactions.

Skills

Computational drug discovery

Structural biology

Molecular docking

Molecular dynamics

Data integration

Biochemical knowledge

Education

Doctorate Degree in related field

Job description

The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) invites applications for a Scientist I to support multidisciplinary infectious-disease drug discovery at WRAIR in Silver Spring, MD.

The role integrates computational drug discovery, structural biology, and experimental biology to identify and optimize therapeutic candidates. The successful candidate will design and apply structure-based and ligand-based approaches, collaborate across biology, chemistry, and