Scientist I, Assay Development for Small Molecule & Antibody Discovery (Biochemistry / Cell Biology)

1910 Genetics; Boston (MA); On-site; USD 80,000 - 110,000; Full time

Job summary

An innovative biotech company is seeking an In Vitro Pharmacology Assay Scientist to drive the discovery of antibodies using cutting-edge AI-driven platforms. This role involves designing and validating biochemical assays, collaborating with scientists, and contributing to scientific discussions. The ideal candidate will possess a PhD in Biology and have extensive experience in antibody drug discovery. Join a dynamic team dedicated to pioneering advancements in drug development and enjoy a supportive work environment that values diversity and inclusion. This is an exciting opportunity to make a significant impact in the biotechnology field.

Benefits

Competitive compensation package

Above market benefits

Generous vacation and parental leave

Team building activities

Great colleagues

Qualifications

• PhD in relevant field with postdoctoral or industry experience in drug discovery.
• Expertise in developing and validating biochemical and cell-based assays.

Responsibilities

• Design and execute in vitro biochemical assays for antibody discovery.
• Collaborate with cross-functional teams to meet project milestones.

Skills

Biochemical characterization

Antibody drug discovery

Problem-solving skills

Data analysis skills

Independent work

Team collaboration

Education

PhD in Biology

Postdoctoral experience

Tools

Chromatographic techniques

SDS-PAGE

UV-Vis spectroscopy

Job description

Company Overview

1910 Genetics is a Series A stage biotechnology company that is pioneering a novel Input-Transform-Output (ITO) platform as the first ever horizontal AI infrastructure for drug discovery.

In a crowded space with hundreds of AI drug discovery companies, 1910's ITO platform is differentiated by:

1. Modality agnostic drug discovery: our platform is capable of designing both small molecule and large molecule therapeutics across all disease areas, with an initial focus on neuroscience, oncology, and autoimmune diseases.
2. Proprietary massive multimodal data, which overcomes the data scarcity problem that prevents frontier AI models from being utilized for drug discovery.
3. Multi-AI agent systems that include a robust collection of frontier AI/ML models, each of which works in a task-oriented manner to achieve the multi-parameter optimization problem of drug discovery and development.
4. A state-of-the-art (SOTA) fully-automated, high throughput wet laboratory in the premier Boston Seaport District for both data generation for AI model training as well as validation of the safety and efficacy of drug candidates that are outputted by our frontier AI models.
5. An unprecedented partnership with Microsoft, which positions 1910 as the only biotech/pharma company leveraging Azure Quantum Elements, a groundbreaking, AI-driven, high performance computing (HPC) cloud architecture for advanced AI.
6. Bespoke conversational AI chatbots that provide a customer friendly UI/UX to access our platform for specific drug discovery tasks.
7. Being the only biotech company helping pharma companies integrate 6 core areas of AI infrastructure.

1910 Genetics is looking for an In Vitro Pharmacology Assay Scientist to work closely with our biologists in the discovery of antibodies. An expert in biochemical characterization of biological drug molecules, the ideal candidate will have experience in antibody drug discovery and characterization of a variety of molecular types.

Role Responsibilities

1. Validate target material in functional biochemical assays prior to the start of antibody discovery.
2. Design, validate and execute in vitro biochemical assays for the screening of molecules from 1910 Genetics' AI-driven large molecule therapeutics platform.
3. Develop, validate and execute assays for the biophysical characterization of antibodies in various formats and for various modalities.
4. Work closely with 1910 scientists to refine assays to help drive delivery of program objectives.
5. Maintain detailed records of experimental procedures and results in electronic lab notebook.
6. Present experimental results/progress in a timely manner and contribute to scientific discussion in group meetings.
7. Collaborate with cross-functional teams, including AI Research and Computational Chemistry to discuss project updates as well as ensure the project milestones and timelines are met.
8. Assist laboratory operations, including maintenance of equipment, reagent tracking and monthly inspections for safety equipment.
9. Develop and execute standard operating procedures and best practices to enhance lab efficiency and productivity.
10. Contribute to the preparation of scientific reports, presentations, and publications.
11. Provide intellectual input into small molecule projects when required.
12. Stay current with scientific literature and emerging technologies in the fields of large and small molecule research.

Qualifications

1. PhD in Biology with a focus on Biochemistry, Cell Biology, In Vitro Pharmacology, Biomedical Sciences or a related field.
2. Postdoctoral experience or relevant industry experience in drug discovery or In Vitro Pharmacology.
3. Experience in developing, validating and implementing biology, biochemical, and cell-based assays.
4. Familiarity with signal transduction pathways in relevant therapeutic areas such as Immunology & Inflammation, neuroscience, oncology, and cardiometabolic diseases.
5. Experience with immune cell isolation and assay development.
6. Experience using analytical techniques/instrumentation for characterization and quantification of large molecules, including chromatographic techniques such as HIC (Hydrophobic Interaction Chromatography) and RP (Reverse Phase), SEC (Size Exclusion Chromatography), SDS-PAGE, UV-Vis, etc.
7. Familiarity with conjugation, purification and characterization of antibody drug conjugates.
8. Excellent problem-solving, critical thinking, and data analysis skills.
9. Ability to work independently and as part of a collaborative team in a fast-paced and dynamic research environment.
10. Strong track record of research accomplishments, as evidenced by publications in scientific journals.

#LI-Onsite

Diversity and Inclusion (1910's Promise)

At 1910, we believe that a diverse, equitable, and inclusive workplace furthers relevance, resilience, and longevity. We encourage people from all backgrounds, ages, abilities, and experiences to apply. 1910 is proud to be an equal-opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status. If, due to a disability, you need an accommodation during any part of the interview process, please let your recruiter know. While 1910 supports visa sponsorship, sponsorship opportunities may be limited to certain roles and skills.

Benefits and Perks

1. Competitive compensation package.
2. Above market benefits.
3. Generous vacation and parental leave.
4. Super cool team building activities.
5. Great colleagues.