Scientist I, Assay Development for Small Molecule & Antibody Discovery (Biochemistry / Cell Biology)

ZipRecruiter; Boston (MA); On-site; USD 85,000 - 120,000; Full time

Job summary

A leading biotechnology company in Boston is looking for an In Vitro Pharmacology Assay Scientist to collaborate in antibody discovery. The role involves validating assays, developing protocols, and contributing to scientific reports. This position demands a PhD and relevant experience to ensure successful drug discovery efforts.

Benefits

Competitive compensation

Above-market benefits

Generous vacation and parental leave

Team-building activities

Collaborative colleagues

Qualifications

• Postdoctoral or industry experience in drug discovery or In Vitro Pharmacology is required.
• Experience developing, validating, and implementing biological and biochemical assays.
• Proven research accomplishments, evidenced by publications.

Responsibilities

• Validate target materials in functional biochemical assays prior to antibody discovery.
• Design and execute in vitro biochemical assays for screening molecules.
• Develop assays for biophysical characterization of antibodies.

Skills

Problem-solving

Critical thinking

Data analysis

Education

PhD in Biology, Biochemistry, Cell Biology, In Vitro Pharmacology or related field

Tools

HIC

RP

SEC

SDS-PAGE

UV-Vis

Job description

Job Description

Company Overview

1910 Genetics is a Series A stage biotechnology company pioneering a novel Input-Transform-Output (ITO) platform as the first horizontal AI infrastructure for drug discovery.

The company's ITO platform is distinguished by:

• Modality-agnostic drug discovery capabilities, designing both small and large molecule therapeutics across various disease areas, initially focusing on neuroscience, oncology, and autoimmune diseases.
• Proprietary large multimodal datasets that address data scarcity issues hindering the use of advanced AI models in drug discovery.
• Multi-AI agent systems comprising frontier AI/ML models that work in a task-oriented manner to optimize drug discovery parameters.
• A state-of-the-art, fully automated high-throughput wet laboratory in Boston's Seaport District for data collection and validation of drug candidates.
• A unique partnership with Microsoft leveraging Azure Quantum Elements, an AI-driven HPC cloud architecture for advanced AI applications.
• Custom conversational AI chatbots providing user-friendly access to our platform for specific drug discovery tasks.
• Support for pharma companies in integrating six core areas of AI infrastructure.

1910 Genetics is seeking an In Vitro Pharmacology Assay Scientist to collaborate with biologists in antibody discovery. The ideal candidate will have expertise in biochemical characterization of biological drug molecules, particularly in antibody drug discovery and molecular characterization.

Role Responsibilities

• Validate target materials in functional biochemical assays prior to antibody discovery.
• Design, validate, and execute in vitro biochemical assays for screening molecules from our AI-driven platform.
• Develop and perform assays for biophysical characterization of antibodies in various formats and modalities.
• Collaborate with scientists to refine assays and meet project objectives.
• Maintain detailed experimental records in electronic lab notebooks.
• Present results and contribute to scientific discussions and group meetings.
• Work with cross-functional teams, including AI Research and Computational Chemistry, to ensure project milestones are met.
• Assist in laboratory operations, equipment maintenance, reagent tracking, and safety inspections.
• Develop SOPs and best practices to improve lab efficiency.
• Contribute to scientific reports, presentations, and publications.
• Provide input on small molecule projects as needed.
• Stay updated with scientific literature and emerging technologies in large and small molecule research.

Qualifications

• PhD in Biology, Biochemistry, Cell Biology, In Vitro Pharmacology, Biomedical Sciences, or related field.
• Postdoctoral or industry experience in drug discovery or In Vitro Pharmacology.
• Experience developing, validating, and implementing biological, biochemical, and cell-based assays.
• Knowledge of signal transduction pathways relevant to immunology, neuroscience, oncology, or cardiometabolic diseases.
• Experience with immune cell isolation and assay development.
• Proficiency with analytical techniques such as HIC, RP, SEC, SDS-PAGE, UV-Vis, for large molecule characterization.
• Familiarity with conjugation, purification, and characterization of antibody-drug conjugates.
• Strong problem-solving, critical thinking, and data analysis skills.
• Ability to work independently and collaboratively in a fast-paced environment.
• Proven research accomplishments, evidenced by publications.

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Our Commitment

We value diversity, equity, and inclusion, believing they enhance our relevance and resilience. We encourage applications from all backgrounds, ages, abilities, and experiences. 1910 is an equal-opportunity employer and supports visa sponsorship, where applicable. If accommodations are needed during the interview process, please inform your recruiter.

Benefits and Perks

• Competitive compensation
• Above-market benefits
• Generous vacation and parental leave
• Team-building activities
• Collaborative colleagues