Scientist Disease Biology Discovery Research

BioSpace; South San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Health insurance

Retirement plan

Paid time off

Flexible work options

Job summary

Amgen in South San Francisco is seeking a Scientist in Disease Biology Discovery Research to advance preclinical targets. You will design and execute in vitro and ex vivo experiments to understand disease biology, and collaborate across teams to push promising targets toward clinical development.

Must have deep molecular and cell biology expertise and strong communication. This permanent role offers a path for career growth within Cardiometabolic Disorders research, with opportunities to publish

Qualifications

• PhD or MSc with relevant molecular/cell biology experience
• Extensive lab experience in cell-based, molecular and biochemical techniques
• Strong data analysis and interpretation skills
• Excellent written and oral communication; collaborative mindset

Responsibilities

• Design and execute in vitro and ex vivo mechanism-of-action experiments
• Generate robust data for preclinical target validation
• Present findings in written and oral formats
• Collaborate with cross-functional drug development teams

Skills

Molecular biology

Cell biology

Interpersonal skills

Communication

Education

PhD

Masters in Molecular & Cell Biology

Bachelors in Molecular & Cell Biology

Tools

RNA isolation/qPCR

Protein immunoprecipitation

Immunoblotting

ELISA

Flow cytometry

Cell imaging & image processing

CRISPR

Virus-based stable cell lines

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared mission to serve patients living with serious illnesses drives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist Disease Biology Discovery Research

What you will do

Lets do this. Lets change the world. In this vital role you will commit to developing a deep understanding of disease biology, identify novel drug targets in the non-oncology space, and play a pivotal role in advancing our pre-clinical pipeline.

This position is within the Cardiometabolic Disorders Department of Amgen Research in South San Francisco. You will join a team of dedicated scientists committed to finding treatments for a diverse set of disease indications, including but not limited to cardiac, cardiovascular, fibrotic, and renal diseases.

To be successful in this role, you will need to have great molecular and cell biology laboratory skills, deep scientific curiosity, and strong interpersonal and communication skills to thrive in a collaborative environment. This is a permanent role that offers opportunities for advancement and career development.

If you have a passion for science and want to be part of an organization discovering new medicines that will impact patients lives, we invite you to join us!

Key Responsibilities

Work collaboratively with a team of experts to generate robust data to support the preclinical validation of novel therapeutic targets and to advance the understanding of disease biology.

Independently design and execute in vitro and ex vivo mechanism-of-action experiments, including troubleshooting, assay optimization, and data collection, analysis, and interpretation.

Present research findings effectively in both written and oral formats for internal teams and external collaborators.

Participating in cross-functional drug development teams as a key intellectual and technical contributor

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dedicated professional we seek is a highly motivated laboratory scientist with these qualifications.

Basic Qualifications

Doctorate degree PhD

OR

Masters degree and 2 years of Molecular and Cell Biology experience

OR

Bachelors degree and 4 years of Molecular and Cell Biology experience

Preferred Qualifications

Extensive experience in cell-based, molecular and biochemical techniques, including RNA isolation/qPCR, protein immunoprecipitation, immunoblotting, ELISA, flow cytometry, and cell imaging and image processing.

Extensive experience in performing in vitro and cellular assays to dissect the function of genes of interest or the mechanism of action of therapeutic molecules as demonstrated by high-impact publications.

Strong interpersonal and organizational skills, a high level of accuracy, commitment to record keeping, and attention to details.

Expertise with cell line engineering technologies, including CRISPR and virus-based stable cell line generation is preferred

Demonstrated experience analyzing and interpreting complex datasets.

Expertise with human iPSCs, especially iPSC-derived cardiomyocytes, is preferred

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

Stock-based long-term incentives

Award-winning time-off plans

Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.

We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation.