Scientist, Pathology

Initial Therapeutics, Inc.; South San Francisco (CA); On-site; USD 120,000 - 190,000; Full time

Benefits offered by this job

Comprehensive employee benefits

Award-winning time-off plans

Flexible work models where possible

Job summary

Amgen is seeking a Scientist to join the Pathology Laboratory within the Translational Safety & Risk Sciences (TSRS) Department in South San Francisco, California. The Scientist will develop and apply tissue-based assays, including multiplex assays and digital image analysis, to support target expression studies, preclinical model development, pharmacodynamics, efficacy, and biomarker discovery.

Responsibilities include developing and validating histopathology assays, using imaging modalities,

Qualifications

• Doctorate or masters plus years of relevant research and industry experience.
• Experience with pathology-based methods, including IHC, multiplex IHC, ISH.
• Strong imaging and digital pathology exposure.

Responsibilities

• Develop, optimize, validate, and standardize histopathology assays on FFPE samples including IHC/ISH.
• Use imaging and digital pathology tools to analyze tissue-based data for biomarker development.
• Collaborate with pathologists and translational teams to support mechanism-of-action studies and safety assessments.
• Maintain documentation and communicate results through LIS, databases, and presentations.

Skills

Histopathology

IHC

ISH

Digital pathology

Image analysis

Team collaboration

Communication

Education

PhD in related field

Masters + 2+ years experience

Bachelors + 4 years experience

Tools

HALO

Visiopharm

Ventana

Leica Bond

IntelliPATH

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist

What you will do

Lets do this. Lets change the world.

Amgen is seeking a Scientist to join the Pathology Laboratory within the Translational Safety & Risk Sciences (TSRS) Department in South San Francisco, California. The Scientist will develop and apply tissue-based assays, including multiplex assays and digital image analysis, to support target expression studies, preclinical model development, pharmacodynamics, efficacy, and biomarker discovery.

Responsibilities:

• Develop, optimize, validate, and standardize histopathology assays using FFPE samples, including single-plex and multiplex immunohistochemistry (IHC) and in situ hybridization (ISH) in colorimetric and immunofluorescent formats.
• Use imaging modalities and digital pathology tools to generate, analyze, and interpret tissue-based data for target qualification, pharmacodynamic and efficacy assessments, and biomarker development.
• Collaborate with pathologists, research investigators, and translational teams to deliver high-quality data supporting mechanism-of-action studies, in vivo model development, and toxicity assessments across therapeutic areas.
• Maintain clear, complete documentation and communicate results through laboratory information systems, databases, and team presentations.

Basic Qualifications:

Doctorate degree

OR

Masters degree and 2+ years of relevant research and industry experience

OR

Bachelors degree and 4 years of relevant research and industry experience

Preferred Qualifications:

• PhD or masters degree in cell biology, molecular biology, or related discipline.
• Two or more years of molecular pathology experience, preferably in an industry setting.
• Demonstrated expertise in pathology-based methods, including IHC, multiplex IHC, ISH and immunofluorescence imaging.
• Experience with digital pathology and image analysis, preferably using HALO and/or Visiopharm.
• Experience with automated staining platforms, such as Ventana, Leica Bond, or IntelliPATH, is preferred.
• Ability to manage multiple projects and priorities simultaneously.
• Excellent written and verbal communication skills.

Qualifications

• Experience analyzing pathology imaging data, including H&E, IHC, multiplex immunofluorescence, and/or spatial transcriptomics.
• Familiarity with whole-slide imaging and digital pathology platforms, such as HALO or Visiopharm, is preferred.
• Understanding of machine-learning methods for image segmentation, classification, detection, and representation learning.
• Strong communication, organizational, and collaboration skills in multidisciplinary scientific environments.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application deadline

External/Internal postings:

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Internal only posting (or Pre-ID candidate):

Amgen anticipates accepting applications however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.