Scientist, Discovery Immunology

Johnson & Johnson Innovative Medicine

Spring House (PA)

On-site

USD 95,000 - 165,000

Full time

4 days ago

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Job summary

Johnson & Johnson Innovative Medicine in Spring House, PA seeks a Scientist in Discovery Immunology to establish experimental proof of concept for novel biological pathways, enabling advancement of therapies for autoimmune and autoinflammatory diseases.

You will translate insights from human data and literature into hands-on bench studies, develop in vitro and co-culture models, test mechanistic hypotheses, and present rigorous data to guide research direction.

Qualifications

BS/MS in Immunology, Cell Biology, or related field with relevant experience.
Strong foundation in myeloid, stromal, and mucosal biology relevant to immune diseases.
Ability to integrate literature, data, and experiments to test hypotheses.
Familiarity with single-cell, bulk omics, and spatial transcriptomics datasets.
Proven track record of clear scientific communication and collaboration.
Self-motivated with strong attention to detail.

Responsibilities

Establish experimental proof of concept for novel immunology pathways.
Translate insights from human datasets and literature into bench studies.
Develop in vitro and co-culture models for autoimmune diseases.
Design, execute and interpret experiments to test mechanistic hypotheses.
Communicate data-driven recommendations to advance promising biology.

Skills

Scientific communication

Multidisciplinary collaboration

Literature analysis

Independent hypothesis testing

Data interpretation

Attention to detail

Self-motivated

Education

Bachelor's or Master’s in Immunology or related discipline

Tools

Flow cytometry

Imaging assays

ELISA / multiplex cytokine assays

qPCR/transcriptomics

CRISPR-based perturbation

Lentiviral transduction

Organ-on-a-chip/microfluidics

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function

Discovery & Pre-Clinical/Clinical Development

Job Sub Function

Biological Research

Job Category

Scientific/Technology

All Job Posting Locations

Spring House, Pennsylvania, United States of America

Job Description

Scientist Discovery Immunology

About Innovative Medicine

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

About Immunology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are seeking an innovative, scientifically curious bench scientist to join our team in Spring House, PA.

This scientist will establish experimental proof of concept for novel biological pathways in emerging areas of immunology, enabling JJIM to advance impactful new therapies for people with autoimmune and autoinflammatory diseases.

The successful candidate will translate insights from proprietary human datasets, published literature, and computational analyses into focused, hands‑on bench studies. They will develop disease‑relevant in vitro and co‑culture models; design, execute, and interpret experiments that test key mechanistic hypotheses; and generate rigorous proof‑of‑concept data to validate emerging pathways and therapeutic opportunities. Working across multidisciplinary teams, they will use experimental findings to refine research direction and clearly communicate recommendations that support progression of the most compelling biology.

Qualifications

B.S. or M.S. in Immunology, Cell Biology, or a related discipline, with relevant academic or industry research experience.

Strong foundation in myeloid, stromal, and mucosal biology and familiarity with how these compartments contribute to chronic inflammation, tissue damage, and healing in immune‑mediated diseases affecting the gut, joint, lung, and skin.

Ability to integrate literature, multidimensional biological data, and experimental findings to generate and independently test mechanistic hypotheses.

Familiarity with single-cell, bulk omics, and spatial transcriptomic datasets and their application to experimental design.

A proven track record demonstrating clear scientific communication and effective multidisciplinary collaboration

Self‑motivated, proactive, strong attention to detail

Technical Skills & Experimental Expertise

Culture, manipulation, isolation, and functional characterization of human cell lines and primary immune or tissue‑derived cells.

Development and optimization of physiologically relevant and fit‑for‑purpose in vitro, co‑culture, and ex vivo models for human disease biology.

Multiparameter flow cytometry, imaging‑based assays, and analysis of cellular phenotype, function, and cell–cell interactions.

Protein and gene‑expression analysis using ELISA, multiplex cytokine assays, qPCR, and transcriptomic approaches.

Familiarity with cell‑engineering methods, including lentiviral transduction, siRNA, and CRISPR‑based perturbation.

Familiarity with organ‑on‑a‑chip and microfluidics‑based culture systems for primary cells is preferred

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers . Internal employees contact AskGS to be directed to your accommodation resource.

Preferred Skills