Scientist, Discovery Immunology

6084-Janssen Research & Development, LLC Legal Entity; Spring House (PA); On-site; USD 90,000 - 150,000; Full time

Job summary

Johnson & Johnson's Immunology team in Spring House, PA is seeking a Scientist to establish experimental proof-of-concept for novel immunology pathways and to translate insights into potential therapies. You will design and execute in vitro, co-culture, and ex vivo models, integrating literature with proprietary data to guide research directions.

Collaboration across multidisciplinary teams is essential. Ideal candidates will have a strong background in immune-mediated diseases, experience with

Qualifications

• B.S. or M.S. in Immunology, Cell Biology, or a related discipline with relevant research experience.
• Strong foundation in myeloid, stromal, and mucosal biology relevant to immune-mediated diseases.
• Ability to integrate literature, data, and experiments to test mechanistic hypotheses.
• Familiarity with single-cell, bulk omics, and spatial transcriptomics datasets.
• Proven track record of scientific communication and cross-disciplinary collaboration.

Responsibilities

• Establish experimental proof-of-concept for novel immunology pathways.
• Develop in vitro, co-culture, and ex vivo disease models.
• Design, execute, and interpret experiments to test hypotheses.
• Translate insights from data and literature into focused research directions and recommendations.

Skills

Scientific communication

Collaboration across multidisciplinary

Experimental design

Literature integration

Data interpretation

Education

B.S./M.S. in Immunology or Cell Biology

Tools

Flow cytometry

Imaging-based assays

qPCR/Transcriptomics

Single-cell omics

Lentiviral transduction

CRISPR perturbation

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow,and profoundly impact health for humanity.Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Biological Research

Job Category: Scientific/Technology

All Job Posting Locations: Spring House, Pennsylvania, United States of America

About Innovative Medicine

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

About Immunology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Scientist – Discovery Immunology

We are seeking an innovative, scientifically curious bench scientist to join our team in Spring House, PA. This scientist will establish experimental proof of concept for novel biological pathways in emerging areas of immunology, enabling JJIM to advance impactful new therapies for people with autoimmune and autoinflammatory diseases. The successful candidate will translate insights from proprietary human datasets, published literature, and computational analyses into focused, hands‑on bench studies. They will develop disease‑relevant in vitro and co‑culture models; design, execute, and interpret experiments that test key mechanistic hypotheses; and generate rigorous proof‑of‑concept data to validate emerging pathways and therapeutic opportunities. Working across multidisciplinary teams, they will use experimental findings to refine research direction and clearly communicate recommendations that support progression of the most compelling biology.

Qualifications

• B.S. or M.S. in Immunology, Cell Biology, or a related discipline, with relevant academic or industry research experience.
• Strong foundation in myeloid, stromal, and mucosal biology and familiarity with how these compartments contribute to chronic inflammation, tissue damage, and healing in immune‑mediated diseases affecting the gut, joint, lung, and skin.
• Ability to integrate literature, multidimensional biological data, and experimental findings to generate and independently test mechanistic hypotheses.
• Familiarity with single‑cell, bulk omics, and spatial transcriptomic datasets and their application to experimental design.
• A proven track record demonstrating clear scientific communication and effective multidisciplinary collaboration.
• Self‑motivated, proactive, strong attention to detail.

Technical Skills & Experimental Expertise

• Culture, manipulation, isolation, and functional characterization of human cell lines and primary immune or tissue‑derived cells.
• Development and optimization of physiologically relevant and fit‑for‑purpose in vitro, co‑culture, and ex vivo models for human disease biology.
• Multiparameter flow cytometry, imaging‑based assays, and analysis of cellular phenotype, function, and cell‑cell interactions.
• Protein and gene‑expression analysis using ELISA, multiplex cytokine assays, qPCR, and transcriptomic approaches.
• Familiarity with cell‑engineering methods, including lentiviral transduction, siRNA, and CRISPR‑based perturbation.
• Familiarity with organ‑on‑a‑chip and microfluidics‑based culture systems for primary cells is preferred.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs.

#LI-Onsite Required Skills: Preferred Skills: Analytical Reasoning, Clinical Data Management, Communication, Data Analysis, Data Compilation, Data Savvy, Design of Experiments (DOE), Drug Discovery Development, Innovation, Molecular Diagnostics, Pharmaceutical Microbiology, Product Knowledge, Project Management, Scientific Research, Technologically Savvy