Scientist, Discovery Immunology

Lifordi Immunotherapeutics, Inc.; Lebanon (NH); On-site; USD 70,000 - 110,000; Full time

Job summary

An innovative firm is seeking a passionate Scientist to join its research team in Lebanon, NH. This exciting full-time role involves developing novel siRNA/ASO therapeutics aimed at addressing chronic inflammatory and autoimmune diseases. The ideal candidate will have a Ph.D. in a relevant scientific discipline and a strong background in RNA therapeutics and immunology. You will be responsible for establishing assays, contributing to drug discovery programs, and communicating findings effectively within a dynamic research environment. If you are self-motivated, creative, and eager to make a significant impact in a vibrant start-up atmosphere, this opportunity is for you!

Qualifications

• Ph.D. in RNA Biochemistry or related field required.
• Strong background in molecular and cell biology essential.

Responsibilities

• Develop assays to support drug discovery and optimization.
• Communicate high-quality data and manage project strategies.

Skills

RNA Biochemistry

Immunology

Cell-based assays

Data generation and documentation

Problem-solving

Communication skills

Education

Ph.D. in Biochemistry or related field

MS with ≥2 years’ experience

Tools

ELISA

Flow cytometry

Cell culture techniques

Job description

This is a full-time, on-site position in Lebanon, NH.

We are seeking a highly motivated and experienced Scientist to join our research team located in Lebanon, New Hampshire to develop novel siRNA/ASO therapeutics for disease areas such as chronic inflammatory and autoimmune diseases. The ideal candidate will have a Ph.D. in RNA Biochemistry, Th2 and/or IBD immunology or an equivalent scientific discipline. Proficiency with immunological cell-based assays, in particular specialized Th1/Th2 assays and M1/M2 assays is a plus. The ideal candidate is a great team player with solid bench skills, self-accountability, with high quality data generation, documentation, and presentation skills.

Successful candidates should be self-motivated, highly creative, have significant experience and mechanistic understanding of aspects of the RNA life cycle (e.g. mRNA processing, RNA degradation, mRNA translation, immunogenicity), and have a passion to develop and move research programs forward in a vibrant start-up environment.

Key Responsibilities:

• Develop and establish assays (cell culture and biochemical activity assays) to support hit-to-lead (H2L) and lead optimization
• Contribute to drug discovery programs, leading project execution with a focus on R&D outcomes
• Design and perform mechanism of action studies
• Implement cellular assays to study nucleic acid biology and the effect of nucleic acid manipulation (e.g., reporter assays, ASO or siRNA approaches and mutagenesis)
• Provide and communicate high-quality data on time and document results as requested
• Create and implement project strategies to identify high-quality development drug candidates, identify key decision points, and manage risk
• Identify and develop short-, mid-, and long-term R&D objectives alongside senior management
• Prioritize and coordinate research activities and allocate resources between internal staff and external contract research organizations (CROs)
• Proactively communicate project strategy, anticipate potential issues, and recommend appropriate resource decisions
• Communicate closely with internal and external team members across multiple disciplines to achieve project goals

Qualifications:

• Ph.D. in Biochemistry, Biophysics, Molecular Biology, mRNA delivery, Th2 and/or IBD immunology or an equivalent scientific discipline, or MS with ≥2 years’ experience in a biotech/pharma
• Knowledge of RNA therapeutics more broadly, RNA delivery, RNA/DNA design, and immunogenicity
• Strong molecular and cell biology background in discovery research
• Well-versed in RNA/DNA molecular biology methods as evidenced by publications in relevant journals or patents
• Proficiency in using a wide range of laboratory techniques including extensive experience in basic immunological techniques such as Th1/Th2 T cell assays, ELISA, flow cytometry, T/B/myeloid cell functional assays, and immune cell isolation is desired
• Excellent lab practice and sterile techniques required
• High level of curiosity, willingness to problem-solve, high motivation to learn new skills, and excellent accountability and organization skills are desired
• High level of initiative in a small company environment including being a self-starter
• Excellent communication and interpersonal skills
• Experience working in dynamic, productive, cross-functional internal and external teams
• Possess outstanding organizational abilities with a collaborative, tactful, and goal-oriented working style

To apply, please send your information and resume to [e-mail].