Scientist - Conjugate

Global Technical Talent; Thousand Oaks (CA); Ibrido; USD 48.000 - 58.000; Tempo pieno

Vantaggi offerti da questo lavoro

Medical, Vision, and Dental Insurance

401k Retirement Fund

Descrizione del lavoro

Global Technical Talent, Inc. in Thousand Oaks seeks a Scientist - Conjugate to join a state‑of‑the‑art research facility on a hybrid schedule.

The position supports the discovery and development of next‑generation antibody‑drug conjugates (ADCs) by integrating bioconjugation chemistry, synthetic chemistry and chemical biology. You will design, generate, purify and characterize ADCs, apply site‑specific and conventional conjugation methods, and perform DAR, purity and aggregation analyses.

Competenze

• Direct experience generating antibody-drug conjugates (ADCs).
• Experience with ADC analytical characterization and quality attributes.
• PhD or equivalent with ADC development exposure; collaboration across teams.

Mansioni

• Design, generate, purify, and characterize ADCs with diverse linker-payload chemistries.
• Use site-specific and conventional conjugation strategies to support programs.
• Analyze DAR, purity, aggregation and heterogeneity; document results clearly.

Conoscenze

ADC generation

Conjugation strategies

Analytical characterization

Communication

Formazione

PhD in chemistry or related field

MS with relevant laboratory experience

BS with 2–3 years ADC experience

Strumenti

HIC

SEC

HPLC

Mass spectrometry

Descrizione del lavoro

Scientist - Conjugate

Location: Thousand Oaks, CA

Onsite Flexibility

Hybrid

Contract Details

• Position Type: Contract
• Contract Duration: 11 months
• Pay Rate: $35.00–$42.00 / Hour (USD)
• Work Authorization: Applicants must be authorized to work for ANY employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

Job Summary

The Emerging Proximity Biology group within the Induced Proximity Platform is seeking a highly motivated scientist to join a state-of-the-art research facility at the client's headquarters campus in Thousand Oaks, CA. The qualified candidate will work at the interface of bioconjugation chemistry, synthetic chemistry, and chemical biology to support the discovery and development of next-generation antibody-drug conjugates (ADCs) incorporating novel therapeutic payloads and linker technologies.

Key Responsibilities

• Design, generate, purify, and characterize antibody-drug conjugates incorporating diverse linker-payload chemistries and novel payloads.
• Utilize varying antibody conjugation strategies, including site-specific and conventional conjugation approaches, to support discovery programs.
• Perform analytical characterization of antibody conjugates, including determination of drug-to-antibody ratio (DAR), assessment of conjugate purity and aggregation, and evaluation of compound heterogeneity.
• Contribute to the design and evaluation of linker-payload constructs, including selection of conjugation chemistries, assessment of synthetic feasibility, and collaboration with chemistry teams to support linker-payload development.
• Collaborate with multidisciplinary teams across chemistry, protein engineering, and biology to advance antibody-based therapeutic modalities.
• Analyze and interpret experimental data, troubleshoot technical challenges, and communicate results through clear documentation, reports, and project updates.

Required Skills

• Hands-on experience with antibody-drug conjugate (ADC) generation, including antibody conjugation, purification, and analytical characterization.
• Experience with analytical techniques relevant to ADC characterization, including hydrophobic interaction chromatography (HIC), size-exclusion chromatography (SEC), HPLC, and mass spectrometry.
• Familiarity with ADC quality attributes, including drug-to-antibody ratio (DAR), conjugate purity, aggregation, and heterogeneity.
• Excellent communication skills.

Preferred Skills

• Strong analytical and problem-solving skills, with the ability to independently troubleshoot experiments, interpret data, and maintain accurate experimental documentation.
• Strong written and verbal communication skills, with the ability to work effectively within multidisciplinary research teams.

Nice-to-Have Experience

• Working knowledge of synthetic organic chemistry, including common chemical transformations, functional group compatibility, and linker design principles.
• Experience with the design, synthesis, or characterization of linker-payload constructs.
• Understanding of ADC biology, including antibody internalization, intracellular payload release, and mechanisms of therapeutic activity.
• Familiarity with emerging therapeutic modalities and their applications in precision oncology and drug discovery.

Education Requirements

• Doctorate in chemistry, chemical biology, biochemistry, or a related scientific discipline; OR
• Master's degree and 1–2 years of relevant laboratory experience; OR
• Bachelor's degree and 2–3 years of relevant laboratory experience.
• Exposure to drug substance and drug product Quality by Design (QbD) processes under cGMP (preferred).
• Hands-on experience with small molecules, antibody-drug conjugates, and peptides (preferred).

Required Experience

• Previous direct experience generating antibody-drug conjugates (ADCs).
• Academic experience is acceptable if the candidate has made and developed ADCs.
• Ph.D.-level candidates may have no industry experience if they have developed ADCs.
• Master's-level candidates should have 1–2 years of relevant experience.

Benefits

• Medical, Vision, and Dental Insurance Plans
• 401k Retirement Fund

Important Notes

• Interview process: Phone interview followed by an on-site interview. Video interview for non-local candidates. A panel interview with the hiring manager and team members is also required.
• Candidates available to start interviewing immediately are preferred.

About GTT

GTT is an NMSDC-certified Minority Business Enterprise (MBE) headquartered in Portsmouth, New Hampshire. GTT is a subsidiary of Chenega Corporation, an Alaska-based company and one of the largest Alaska Native-owned corporations. An Inc. 5000 honoree and one of SIA's Best Staffing Firms to Work For, GTT connects professionals with Fortune 500 organizations across IT, engineering, construction, utilities, life sciences, financial services, and healthcare throughout the U.S. and Canada. We're committed to diverse, inclusive workplaces and to placing people in roles where they can do their best work.

Job Number: 26-18295

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