Scientist, CMC Analytical

Citytherapeutics; Cambridge (MA); On-site; USD 117,000 - 133,000; Full time

Benefits offered by this job

Medical benefits

401(k) with company match

Equity compensation

Job summary

City Therapeutics is seeking a passionate Scientist, CMC Analytical to join our growing team. You will lead method development, qualification, and transfer to support internal labs and external partners.

The role is hands-on and highly cross-functional, partnering with CROs/CMOs to define impurity profiles and deliver comprehensive characterization of oligonucleotide drug substances, drug products, and process intermediates.

Qualifications

• Ph.D. in Analytical Chemistry or related field with 3+ years relevant industry experience; M.S. with 7+ years; or B.S. with 10+ years.
• Strong AX-HPLC and HPLC–MS technical background with hands-on oligonucleotide characterization experience.
• Demonstrated skills in handling, analyzing, and characterizing oligonucleotides and related organic molecules.
• Familiarity with cGxP expectations, analytical data systems, and data integrity principles.
• Knowledge of CMC regulatory requirements (e.g., IND/IMPD) is a plus.
• Meticulous documentation, strong problem‑solving, and the ability to operate with minimal supervision.
• Excellent communication, organization, and teamwork skills; comfortable in a fast-paced, multi‑project environment with shifting priorities.

Responsibilities

• Lead method development, verification/qualification, validation (as needed), and transfer for existing and new programs.
• Develop and implement analytical technology such as HPLC-MS methods for impurity characterizations of oligonucleotides
• Conduct exploratory stability studies for raw materials, intermediates, DS, and DP; interpret trends and recommend actions.
• Generate high-quality data; analyze, interpret, and communicate results;
• Write CMC source documents such as, but not limited to, analytical methods, development reports, qualification/validation protocols and reports
• Operate, calibrate, maintain, and troubleshoot analytical instrumentation; ensure adherence to data integrity and safety practices.

Skills

AX-HPLC

HPLC–MS

Oligonucleotide characterization

Data integrity

Analytical problem-solving

Teamwork

Education

PhD in Analytical Chemistry or related field

MS in Analytical Chemistry or related field

BS in Chemistry or related field

Tools

HPLC instruments

Mass spectrometry (MS)

Job description

Scientist, CMC Analytical

Job Summary

City Therapeutics is seeking a passionate Scientist, CMC Analytical to join our growing team. You will lead method development, qualification, and transfer to support internal labs and external partners. The role is hands‑on and highly cross‑functional, partnering with CROs/CMOs to define impurity profiles and deliver comprehensive characterization of oligonucleotide drug substances, drug products, and process intermediates (e.g., siRNA and conjugates). You will report to the Director, CMC Analytical and contribute directly to City’s next‑generation siRNA programs.

Key Responsibilities

• Lead method development, verification/qualification, validation (as needed), and transfer for existing and new programs.

• Develop and implement analytical technology such as HPLC-MS methods for impurity characterizations of oligonucleotides

• Conduct exploratory stability studies for raw materials, intermediates, DS, and DP; interpret trends and recommend actions.
• Generate high-quality data; analyze, interpret, and communicate results;
• Write CMC source documents such as, but not limited to, analytical methods, development reports, qualification/validation protocols and reports
• Operate, calibrate, maintain, and troubleshoot analytical instrumentation; ensure adherence to data integrity and safety practices.

Qualifications

• Ph.D. in Analytical Chemistry or related field with 3+ years relevant industry experience; M.S. with 7+ years; or B.S. with 10+ years.
• Strong AX-HPLC and HPLC–MS technical background with hands‑on oligonucleotide characterization experience.
• Demonstrated skills in handling, analyzing, and characterizing oligonucleotides and related organic molecules.
• Familiarity with cGxP expectations, analytical data systems, and data integrity principles.
• Knowledge of CMC regulatory requirements (e.g., IND/IMPD) is a plus.
• Meticulous documentation, strong problem‑solving, and the ability to operate with minimal supervision.
• Excellent communication, organization, and teamwork skills; comfortable in a fast‑paced, multi‑project environment with shifting priorities.

Compensation

The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including relevant skills, experience, internal equity, relevant education or training and market dynamics. In addition, this role is eligible for an annual cash bonus and equity compensation. City Therapeutics offers a comprehensive and competitive benefits package including medical, dental, vision, life insurance, health and dependent care FSA accounts, HSA/HRA accounts with company contributions, in addition to a 401(k) with competitive company match. Per Year Salary Range: $117,333 to $132,667

City Therapeutics is an Equal Opportunity and affirming action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.