CMC Analytical Scientist: Lead Oligonucleotide Method Development

Citytherapeutics; Cambridge (MA); On-site; USD 117,000 - 133,000; Full time

Benefits offered by this job

Medical benefits

401(k) with company match

Equity compensation

Job summary

City Therapeutics is seeking a passionate Scientist, CMC Analytical to join our growing team. You will lead method development, qualification, and transfer to support internal labs and external partners.

The role is hands-on and highly cross-functional, partnering with CROs/CMOs to define impurity profiles and deliver comprehensive characterization of oligonucleotide drug substances, drug products, and process intermediates.

Qualifications

• Ph.D. in Analytical Chemistry or related field with 3+ years relevant industry experience; M.S. with 7+ years; or B.S. with 10+ years.
• Strong AX-HPLC and HPLC–MS technical background with hands-on oligonucleotide characterization experience.
• Demonstrated skills in handling, analyzing, and characterizing oligonucleotides and related organic molecules.
• Familiarity with cGxP expectations, analytical data systems, and data integrity principles.
• Knowledge of CMC regulatory requirements (e.g., IND/IMPD) is a plus.
• Meticulous documentation, strong problem‑solving, and the ability to operate with minimal supervision.
• Excellent communication, organization, and teamwork skills; comfortable in a fast-paced, multi‑project environment with shifting priorities.

Responsibilities

• Lead method development, verification/qualification, validation (as needed), and transfer for existing and new programs.
• Develop and implement analytical technology such as HPLC-MS methods for impurity characterizations of oligonucleotides
• Conduct exploratory stability studies for raw materials, intermediates, DS, and DP; interpret trends and recommend actions.
• Generate high-quality data; analyze, interpret, and communicate results;
• Write CMC source documents such as, but not limited to, analytical methods, development reports, qualification/validation protocols and reports
• Operate, calibrate, maintain, and troubleshoot analytical instrumentation; ensure adherence to data integrity and safety practices.

Skills

AX-HPLC

HPLC–MS

Oligonucleotide characterization

Data integrity

Analytical problem-solving

Teamwork

Education

PhD in Analytical Chemistry or related field

MS in Analytical Chemistry or related field

BS in Chemistry or related field

Tools

HPLC instruments

Mass spectrometry (MS)

Job description

City Therapeutics is seeking a passionate Scientist, CMC Analytical to join our growing team. You will lead method development, qualification, and transfer to support internal labs and external partners.

The role is hands-on and highly cross-functional, partnering with CROs/CMOs to define impurity profiles and deliver comprehensive characterization of oligonucleotide drug substances, drug products, and process intermediates.