Senior Scientist, CMC Quality Control

Citytherapeutics; Cambridge (MA); On-site; USD 136,000 - 154,000; Full time

Benefits offered by this job

Comprehensive benefits package

401(k) with competitive match

Annual cash bonus

Equity compensation

Job summary

Citytherapeutics in Cambridge, MA is seeking a Senior Scientist in CMC Quality Control. This role involves leading method verification and managing stability protocols for oligonucleotide drug products.

The ideal candidate will hold a Ph.D. in Analytical Chemistry with experience in the pharmaceutical industry, particularly with analytical instrumentation and oligonucleotide analysis. A comprehensive benefits package accompanies this full-time onsite role, along with an annual cash bonus and equity compensation.

Qualifications

• Ph.D. in Analytical Chemistry or relevant field; M.S. with 7+ years; or B.S. with 10+ years.
• CDMO experience is highly valued.
• Familiarity with cGxP expectations and data integrity principles.

Responsibilities

• Lead method verification and qualification for new programs.
• Manage stability protocols and conduct exploratory stability studies.
• Write analytical methods, qualification protocols, and reports.

Skills

Hands-on oligonucleotide analysis experience

AX-HPLC and HPLC–MS technical background

Analytical instrumentation theory knowledge

Documentation skills

Problem-solving skills

Communication and teamwork skills

Education

Ph.D. in Analytical Chemistry or related field

M.S. with 7+ years industry experience

B.S. with 10+ years industry experience

Job description

Senior Scientist, CMC Quality Control

Job Summary

City Therapeutics is seeking a passionate Senior Scientist, CMC Quality Control to join our growing team. The current focus will be on release and stability management of oligonucleotide drug substances, drug products, and process intermediates (e.g., siRNA and conjugates). You will also lead method transfer and qualification to support internal labs and external partners. This role will report to the Senior Director, CMC AD/QC and contribute directly to City’s next-generation siRNA programs.

Important Note

This is a full-time, onsite opportunity.

Key Responsibilities

• Lead method verification/qualification, validation (as needed), and method transfer for existing and new programs.
• Manage stability protocols and reports from partners
• Conduct exploratory stability studies for raw materials, intermediates, DS, and DP; interpret trends and recommend actions.
• Work both independently and with cross‑functional teams to plan, prioritize, and meet project timelines.
• Write CMC source documents such as, but not limited to, analytical methods, qualification/validation protocols and reports.
• Operate, calibrate, maintain, and troubleshoot analytical instrumentation; ensure adherence to data integrity and safety practices.

Qualifications

• Ph.D. in Analytical Chemistry or related field with 3+ years relevant industry experience; M.S. with 7+ years; or B.S. with 10+ years.
• CDMO experience is highly valued.
• Strong AX-HPLC and HPLC–MS technical background with hands‑on oligonucleotide analysis experience.
• Proven understanding of analytical instrumentation theory and practice across DS/DP development and manufacturing processes.
• Demonstrated skills in handling, analyzing, and characterizing oligonucleotides and related organic molecules.
• Familiarity with cGxP expectations, analytical data systems, and data integrity principles.
• Knowledge of CMC regulatory requirements (e.g., IND/IMPD) is a plus.
• Understanding of basic theories and principles of synthetic organic chemistry is a plus
• Meticulous documentation, strong problem‑solving, and the ability to operate with minimal supervision.
• Excellent communication, organization, and teamwork skills; comfortable in a fast‑paced, multi‑project environment with shifting priorities.

Compensation

The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including relevant skills, experience, internal equity, relevant education or training and market dynamics. In addition, this role is eligible for an annual cash bonus and equity compensation. City Therapeutics offers a comprehensive and competitive benefits package including medical, dental, vision, life insurance, health and dependent care FSA accounts, HSA/HRA accounts with company contributions, in addition to a 401(k) with competitive company match.

Per Year Salary Range: $136,000 to $154,000.

Application Process

City Therapeutics is accepting resumes/CVs from direct applicants only. Recruitment agency submissions will not be accepted at this time.

Equal Opportunity Statement

City Therapeutics is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership, or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing); or any other characteristic protected by law.